Abdou Reham M, Zhu Lixin, Baker Robert D, Baker Susan S
Digestive Diseases and Nutrition Center, Department of Pediatrics, Women and Children's Hospital of Buffalo, The State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.
, 3435 Main Street, 413 Biomedical Research Building, Buffalo, NY, 14214, USA.
Dig Dis Sci. 2016 May;61(5):1268-81. doi: 10.1007/s10620-016-4045-1. Epub 2016 Feb 22.
The prevalence of nonalcoholic fatty liver disease has been rapidly increasing worldwide. It has become a leading cause of liver transplantation. Accumulating evidence suggests a significant role for gut microbiota in its development and progression. Here we review the effect of gut microbiota on developing hepatic fatty infiltration and its progression. Current literature supports a possible role for gut microbiota in the development of liver steatosis, inflammation and fibrosis. We also review the literature on possible interventions for NAFLD that target the gut microbiota.
非酒精性脂肪性肝病在全球范围内的患病率一直在迅速上升。它已成为肝移植的主要原因。越来越多的证据表明肠道微生物群在其发生和发展中起重要作用。在此，我们综述肠道微生物群对肝脏脂肪浸润及其进展的影响。当前文献支持肠道微生物群在肝脂肪变性、炎症和纤维化发生中可能发挥的作用。我们还综述了针对肠道微生物群的非酒精性脂肪性肝病可能干预措施的相关文献。
