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hsp26 of Saccharomyces cerevisiae is related to the superfamily of small heat shock proteins but is without a demonstrable function.

作者信息

Susek R E, Lindquist S L

机构信息

Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.

出版信息

Mol Cell Biol. 1989 Nov;9(11):5265-71. doi: 10.1128/mcb.9.11.5265-5271.1989.

DOI:10.1128/mcb.9.11.5265-5271.1989
PMID:2689876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363685/
Abstract

Analysis of the cloned gene confirms that hsp26 of Saccharomyces cerevisiae is a member of the small heat shock protein superfamily. Previous mutational analysis failed to demonstrate any function for the protein. Further experiments presented here demonstrate that hsp26 has no obvious regulatory role and no major effect on thermotolerance. It is possible that the small heat shock protein genes originated as primitive viral or selfish DNA elements.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f874/363685/0a521bb7a1bb/molcellb00059-0691-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f874/363685/43d09c42da3a/molcellb00059-0690-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f874/363685/0a521bb7a1bb/molcellb00059-0691-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f874/363685/43d09c42da3a/molcellb00059-0690-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f874/363685/0a521bb7a1bb/molcellb00059-0691-a.jpg

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1
hsp26 of Saccharomyces cerevisiae is related to the superfamily of small heat shock proteins but is without a demonstrable function.
Mol Cell Biol. 1989 Nov;9(11):5265-71. doi: 10.1128/mcb.9.11.5265-5271.1989.
2
Structure and expression of a yeast gene encoding the small heat-shock protein Hsp26.
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MSI3, a multicopy suppressor of mutants hyperactivated in the RAS-cAMP pathway, encodes a novel HSP70 protein of Saccharomyces cerevisiae.MSI3是RAS - cAMP途径中过度激活的突变体的多拷贝抑制因子，它编码酿酒酵母的一种新型HSP70蛋白。
Mol Gen Genet. 1993 Sep;240(3):323-32. doi: 10.1007/BF00280382.

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Mechanisms of Small Heat Shock Proteins.小分子热休克蛋白的作用机制。

本文引用的文献

1
Synthesis of the low molecular weight heat shock proteins in plants.植物中低分子量热激蛋白的合成
Plant Physiol. 1987 Aug;84(4):1007-17. doi: 10.1104/pp.84.4.1007.
2
DNA sequence and transcript mapping of a soybean gene encoding a small heat shock protein.大豆小热激蛋白基因的 DNA 序列和转录本作图
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3726-30. doi: 10.1073/pnas.82.11.3726.
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Identification of common molecular subsequences.常见分子子序列的鉴定
Cold Spring Harb Perspect Biol. 2019 Oct 1;11(10):a034025. doi: 10.1101/cshperspect.a034025.
4
Developing a genetic approach to investigate the mechanism of mitochondrial competence for DNA import.开发一种遗传学方法来研究线粒体DNA导入能力的机制。
Biochim Biophys Acta. 2009 May;1787(5):320-7. doi: 10.1016/j.bbabio.2008.11.001. Epub 2008 Nov 12.
5
The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance.热休克蛋白27（Hsp27）基因对果蝇发育并非必需，但其活性与抗饥饿能力相关。
Cell Stress Chaperones. 2007 Winter;12(4):364-72. doi: 10.1379/csc-308.1.
6
A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.蛋白质解聚中的伴侣蛋白途径。Hsp26改变蛋白质聚集体的性质，以促进Hsp104介导的再激活。
J Biol Chem. 2005 Jun 24;280(25):23869-75. doi: 10.1074/jbc.M502854200. Epub 2005 Apr 20.
7
Validation of a flour-free model dough system for throughput studies of baker's yeast.用于面包酵母通量研究的无面粉模型面团系统的验证
Appl Environ Microbiol. 2005 Mar;71(3):1142-7. doi: 10.1128/AEM.71.3.1142-1147.2005.
8
Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae.蛋白激酶A以不依赖Msn2/4p且依赖Hsf1p的方式调控酿酒酵母中小热休克基因的组成型表达。
Genetics. 2005 Mar;169(3):1203-14. doi: 10.1534/genetics.104.034256. Epub 2004 Nov 15.
9
Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae.Hsp42是酿酒酵母细胞质中的一种常见小分子热休克蛋白。
EMBO J. 2004 Feb 11;23(3):638-49. doi: 10.1038/sj.emboj.7600080. Epub 2004 Jan 29.
10
Differences in properties between human alphaA- and alphaB-crystallin proteins expressed in Escherichia coli cells in response to cold and extreme pH.在大肠杆菌细胞中表达的人αA-和αB-晶状体蛋白在应对寒冷和极端pH值时的性质差异。
Biochem J. 2003 Oct 15;375(Pt 2):471-5. doi: 10.1042/BJ20030748.
J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.
4
Recognition of protein coding regions in DNA sequences.DNA序列中蛋白质编码区域的识别。
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5
A simple method for displaying the hydropathic character of a protein.一种展示蛋白质亲水性特征的简单方法。
J Mol Biol. 1982 May 5;157(1):105-32. doi: 10.1016/0022-2836(82)90515-0.
6
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7
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Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.缓冲液梯度凝胶和35S标记辅助快速DNA序列测定。
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Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast.构建并使用在酵母中表达的与lacZ（β-半乳糖苷酶）的基因融合体。
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Proc Natl Acad Sci U S A. 1982 Apr;79(7):2360-4. doi: 10.1073/pnas.79.7.2360.