Department of Clinical and Basic Neuroscience, King's College London, London, UK.
Department of Pharmacy, University of Parma, Parma, Italy.
Trends Biochem Sci. 2016 Apr;41(4):371-385. doi: 10.1016/j.tibs.2016.01.006. Epub 2016 Feb 15.
Ubiquitylation is a post-translational modification implicated in several different cellular pathways. The possibility of forming chains through covalent crosslinking between any of the seven lysines, or the initial methionine, and the C terminus of another moiety provides ubiquitin (Ub) with special flexibility in its function in signalling. Here, we review the knowledge accumulated over the past several years about the functions and structural features of polyUb chains. This analysis reveals the need to understand further the functional role of some of the linkages and the structural code that determines recognition of polyUbs by protein partners.
泛素化是一种翻译后修饰，涉及多种不同的细胞途径。通过在任何七个赖氨酸中的任何一个、或起始甲硫氨酸与另一部分的 C 末端之间形成共价交联链的可能性，赋予了泛素（Ub）在信号转导功能中的特殊灵活性。在这里，我们回顾了过去几年积累的关于多泛素链的功能和结构特征的知识。这种分析揭示了需要进一步了解一些连接的功能作用以及决定蛋白伴侣识别多泛素的结构密码。
