Chen Shuang, Guo Xiaofan, Yu Shasha, Zhou Ying, Li Zhao, Sun Yingxian
Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang 110000, China.
Int J Environ Res Public Health. 2016 Feb 17;13(2):223. doi: 10.3390/ijerph13020223.
The aim of this study was to evaluate the associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with metabolic syndrome (MetS) in the general Chinese population.
This study was a multicenter, cross-sectional study which was conducted in rural areas of China from the 2012 to 2013 Northeast China Rural Cardiovascular Health Study (NCRCHS), and 11,573 adults with complete data were included in our final analysis. Elevated ALT and AST levels were defined as >40 U/L. Serum ALT and AST levels within the reference range were divided into quartiles, and their associations with MetS were evaluated by logistic regressions.
A total of 7.4% and 3.5% participants had elevated serum ALT and AST levels, respectively. The prevalence of MetS was 37.3% in males and 45.8% in females. After adjusting for potential confounders, we found ALT level elevation, even within the reference range, was independently associated with MetS. The odds ratio (OR) values of MetS in the ALT quartiles 2-4 groups within the reference range were 1.113 (95% CI: 1.019-1.280), 1.375 (95% CI: 1.212-1.560), 1.878 (95% CI: 1.650-2.138) compared with the ALT quartile 1 group, and OR in the elevated ALT group was 3.020 (95% CI: 2.496-3.653). Positive relationship for MetS was also observed in elevated AST group (OR: 1.689, 95% CI: 1.314-2.171), but within the reference range, the AST level was not associated with MetS.
Serum ALT level, even within the reference range, was significantly associated with MetS. However, only elevated AST levels above 40 U/L was positively associated with MetS. Within the reference range, we did not find a relationship between AST levels and MetS.
本研究旨在评估中国普通人群中丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）与代谢综合征（MetS）之间的关联。
本研究为多中心横断面研究，于2012年至2013年在中国东北地区农村心血管健康研究（NCRCHS）的农村地区开展，最终纳入11,573名有完整数据的成年人。ALT和AST水平升高定义为>40 U/L。将参考范围内的血清ALT和AST水平分为四分位数，并通过逻辑回归评估它们与MetS的关联。
分别有7.4%和3.5%的参与者血清ALT和AST水平升高。男性MetS患病率为37.3%，女性为45.8%。在调整潜在混杂因素后，我们发现即使在参考范围内，ALT水平升高也与MetS独立相关。参考范围内ALT四分位数2-4组中MetS的比值比（OR）值分别为1.113（95%CI：1.019-1.280）、1.375（95%CI：1.212-1.560）、1.878（95%CI：1.650-2.138），与ALT四分位数1组相比，ALT升高组的OR为3.020（95%CI：2.496-3.653）。AST升高组中也观察到与MetS呈正相关（OR：1.689，95%CI：1.314-2.171），但在参考范围内，AST水平与MetS无关。
血清ALT水平即使在参考范围内也与MetS显著相关。然而，仅AST水平高于40 U/L时才与MetS呈正相关。在参考范围内，我们未发现AST水平与MetS之间存在关联。
