Lamou Bonoy, Taiwe Germain Sotoing, Hamadou André, Houlray Justin, Atour Mahamat Mey, Tan Paul Vernyuy
Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P. O. Box 812, Yaoundé, Cameroon.
Department of Animal Biology and Physiology, Faculty of Science, University of Buea, P. O. Box 63, Yaoundé, Cameroon.
Oxid Med Cell Longev. 2016;2016:3517824. doi: 10.1155/2016/3517824. Epub 2016 Jan 19.
The effects of the aqueous extract of Moringa oleifera on swimming performance and related biochemical parameters were investigated in male Wistar rats (130-132 g). Four groups of rats (16 per group) were fed a standard laboratory diet and given distilled water, 100, 200, or 400 mg/kg of extract, respectively, for 28 days. On day 28, 8 rats from each group were subjected to the forced swimming test with tail load (10% of body weight). The remaining 8 rats per group were subjected to the 90-minute free swim. Maximum swimming time, glycemia, lactamia, uremia, triglyceridemia, hepatic and muscle glycogen, hematological parameters, and oxidative stress parameters (superoxide dismutase, catalase, reduced glutathione, and malondialdehyde) were measured. Results. M. oleifera extract increased maximum swimming time, blood hemoglobin, blood glucose, and hepatic and muscle glycogen reserves. The extract also increased the activity of antioxidant enzymes and decreased the blood concentrations of malondialdehyde. Furthermore, it decreased blood concentrations of lactate, triglycerides, and urea. In conclusion, the antifatigue properties of M. oleifera extract are demonstrated by its ability to improve body energy stores and tissue antioxidant capacity and to reduce the tissue build-up of lactic acid.
在雄性Wistar大鼠（130 - 132克）中研究了辣木水提取物对游泳能力及相关生化参数的影响。四组大鼠（每组16只）喂食标准实验室饲料，并分别给予蒸馏水、100、200或400毫克/千克提取物，持续28天。在第28天，每组8只大鼠进行负重（体重的10%）强迫游泳试验。每组其余8只大鼠进行90分钟自由游泳。测量最大游泳时间、血糖、血乳酸、血尿素氮、甘油三酯血症、肝糖原和肌糖原、血液学参数以及氧化应激参数（超氧化物歧化酶、过氧化氢酶、还原型谷胱甘肽和丙二醛）。结果。辣木提取物增加了最大游泳时间、血红蛋白、血糖以及肝糖原和肌糖原储备。该提取物还提高了抗氧化酶的活性，并降低了丙二醛的血浓度。此外，它降低了乳酸、甘油三酯和尿素的血浓度。总之，辣木提取物的抗疲劳特性表现为其能够改善机体能量储备和组织抗氧化能力，并减少组织中乳酸的积累。
