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不同无色杆菌属物种中固有外排介导的氨基糖苷类耐药性分布情况

Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species.

作者信息

Bador J, Neuwirth C, Liszczynski P, Mézier M-C, Chrétiennot M, Grenot E, Chapuis A, de Curraize C, Amoureux L

机构信息

Department of Bacteriology, University Hospital of Dijon, Dijon, France.

出版信息

New Microbes New Infect. 2015 Dec 12;10:1-5. doi: 10.1016/j.nmni.2015.11.013. eCollection 2016 Mar.

DOI:10.1016/j.nmni.2015.11.013
PMID:26904200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4726742/
Abstract

Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis.

摘要

无色杆菌属细菌是囊性纤维化患者中新出现的呼吸道病原体。自2013年以来，无色杆菌属包括15个物种，其天然抗生素耐药性尚不清楚。此前已描述AxyXY - OprZ外排系统赋予木糖氧化无色杆菌对氨基糖苷类（AG）的耐药性。然而，一些无色杆菌属菌株对AG敏感。这项包含49株无色杆菌分离株的研究表明，AG耐药性与不同的无色杆菌属物种相关。值得注意的是，axyXY - oprZ操纵子仅在对AG耐药的物种中检测到，包括在囊性纤维化患者中最常遇到的：木糖氧化无色杆菌、鲁氏无色杆菌、多伦斯无色杆菌和不活跃无色杆菌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2741/4726742/2eeb714acc32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2741/4726742/92c5fdf68fef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2741/4726742/2eeb714acc32/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2741/4726742/92c5fdf68fef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2741/4726742/2eeb714acc32/gr2.jpg

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