Daniel H I, Molta N B
Department of Pharmacology, University of Maiduguri.
Ann Trop Med Parasitol. 1989 Aug;83(4):331-8. doi: 10.1080/00034983.1989.11812353.
The Nigerian Federal Ministry of Health in 1987 instituted a nationwide programme to gather data on the efficacy of chloroquine in treating malaria in children as a basis for the development of a national malaria therapy policy. The programme is part of a comprehensive Combating Childhood Communicable Diseases (CCCD) programme. A simplified WHO in vivo method, involving follow-up observations on day 1 (D1), D2, D7 and D14 following the first day the study began (D0), was used for this study. A total of 769 children were screened, of which 363 (47%) were positive for malaria parasites. Fifty-three children were enrolled for the 14-day follow up, and chloroquine phosphate, 25 mg (base) kg-1, was given in three divided doses on D0, D1 and D2. Parasitological failure occurred in 25% of the children. There were no clinical failures in the study; i.e. no child found with parasitaemia after completing treatment was judged to be clinically ill. Generally the older children had the heavier parasite densities and severer symptoms.
1987年，尼日利亚联邦卫生部启动了一项全国性计划，收集有关氯喹治疗儿童疟疾疗效的数据，作为制定国家疟疾治疗政策的依据。该计划是综合防治儿童传染病（CCCD）计划的一部分。本研究采用了一种简化的世卫组织体内方法，即在研究开始首日（D0）之后的第1天（D1）、第2天、第7天和第14天进行随访观察。总共筛查了769名儿童，其中363名（47%）疟原虫呈阳性。53名儿童参与了为期14天的随访，在D0、D1和D2日分三次给予25毫克（碱基）/千克的磷酸氯喹。25%的儿童出现寄生虫学治疗失败。本研究中无临床治疗失败情况；也就是说，完成治疗后未发现有寄生虫血症的儿童被判定为无临床疾病。一般来说，年龄较大的儿童寄生虫密度更高，症状更严重。
