Park Chun Shik, Shen Ye, Lewis Andrew, Lacorazza H Daniel
Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and.
Department of Pathology & Immunology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA; and Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA
J Leukoc Biol. 2016 May;99(5):673-85. doi: 10.1189/jlb.1RU1215-539R. Epub 2016 Feb 23.
Krüppel-like factor 4 is a zinc finger protein with dual functions that can act as a transcriptional activator and repressor of genes involved in cell proliferation, differentiation, and apoptosis. Although most studies have focused on terminally differentiated epithelial cells, evidence suggests that Krüppel-like factor 4 regulates the development and function of the myeloid and lymphoid blood lineages. The ability of Krüppel-like factor 4 to dedifferentiate from somatic cells into pluripotent stem cells in cooperation with other reprogramming factors suggests its potential function in the preservation of tissue-specific stem cells. Additionally, emerging interest in the redifferentiation of induced pluripotent stem cells into blood cells to correct hematologic deficiencies and malignancies warrants further studies on the role of Krüppel-like factor 4 in steady-state blood formation.
Krüppel样因子4是一种具有双重功能的锌指蛋白，可作为参与细胞增殖、分化和凋亡的基因的转录激活因子和抑制因子。尽管大多数研究集中在终末分化的上皮细胞上，但有证据表明Krüppel样因子4调节髓系和淋巴系血细胞的发育和功能。Krüppel样因子4与其他重编程因子协同作用，从体细胞去分化为多能干细胞的能力表明其在组织特异性干细胞维持中的潜在功能。此外，诱导多能干细胞再分化为血细胞以纠正血液系统缺陷和恶性肿瘤的研究兴趣日益浓厚，这使得有必要进一步研究Krüppel样因子4在稳态血液形成中的作用。
