Chongruksut Wilaiwan, Limpakan Yamada Sirikan, Chakrabandhu Bandhuphat, Ruengorn Chidchanok, Nanta Sirisak
Wilaiwan Chongruksut, Sirikan Limpakan (Yamada), Bandhuphat Chakrabandhu, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
World J Gastrointest Oncol. 2016 Feb 15;8(2):215-21. doi: 10.4251/wjgo.v8.i2.215.
To evaluate (1) the association of the Helicobacter pylori (H. pylori) test and interleukin-8 (IL-8) mRNA expression alone and the severity of gastric cancer (GC); (2) the association of both tests were added to patients' characteristics to identifli Thai suspected patients of gastric cancer who would receive the most benefit; and (3) diagnostic value of levels of IL-8 mRNA expression for gastric cancer.
A cross-sectional analytical study was completed with 220 patients with 86 GC patients who underwent endoscopy with gastric surgery divided into non-metastasis and metastasis groups, and 134 patients with benign lesions who underwent endoscopic examination, at the Gastrointestinal Surgery and Endoscopy Unit, Chiang Mai University Hospital between 2006 and 2010. Of 220 patients, 86 cases of diagnosed gastric adenocarcinoma were in an advanced stage and 134 cases were non-cancer patients.
The IL-8 mRNA expression showed predominant association with advanced GC when compared to H. pylori infection alone [OR (95%CI); 0.86 (0.49-1.53) vs 5.44 (3.08-9.62)] when including the patients' characteristics the highest of the area under the receiver operating characteristic curves (AuROC) of the model were males older than 40 years of age [AuROC (95%CI); 0.81 (0.75-0.86)]. However, preliminary testing for diagnostic indices of four cut-off points of IL-8 mRNA expression to predict the severity of GC cases found an increasing suboptimal trend from the likelihood ratio of positive to differentiate the severity in the GC group. The IL-8 mRNA expression showed a predominant association with GC when compared to H. pylori infection, especially in males older than 40 years of age who may benefit most from this test.
The future research of IL-8 mRNA expression to predict severity in the gastric cancer group should be warranted.
评估（1）幽门螺杆菌（H. pylori）检测及白细胞介素-8（IL-8）mRNA表达单独与胃癌（GC）严重程度之间的关联；（2）将这两项检测与患者特征相结合，以识别出可能从检测中获益最大的泰国胃癌疑似患者；（3）IL-8 mRNA表达水平对胃癌的诊断价值。
2006年至2010年间，在清迈大学医院胃肠外科和内镜科对220例患者进行了一项横断面分析研究。其中86例接受了胃手术的GC患者接受了内镜检查，分为非转移组和转移组；134例接受内镜检查的良性病变患者。220例患者中，86例被诊断为晚期胃腺癌，134例为非癌症患者。
与单独的幽门螺杆菌感染相比，IL-8 mRNA表达与晚期GC的关联性更为显著[比值比（95%可信区间）；0.86（0.49 - 1.53）对5.44（3.08 - 9.62）]。纳入患者特征后，模型的受试者操作特征曲线下面积（AuROC）最高的是年龄大于40岁的男性[AuROC（95%可信区间）；0.81（0.75 - 0.86）]。然而，对IL-8 mRNA表达的四个截断点进行诊断指标的初步测试，以预测GC病例的严重程度，发现从阳性似然比区分GC组严重程度呈现出次优趋势增加。与幽门螺杆菌感染相比，IL-8 mRNA表达与GC的关联性更为显著，尤其是年龄大于40岁的男性可能从该检测中获益最大。
对IL-8 mRNA表达预测胃癌组严重程度的未来研究是有必要的。
