社会心理经济不稳定、认知衰退与患痴呆症风险：一项为期25年的研究
Psychosocioeconomic Precariousness, Cognitive Decline and Risk of Developing Dementia: A 25-Year Study.
作者信息
Ouvrard Camille, Meillon Céline, Dartigues Jean-François, Ávila-Funes José Alberto, Amieva Hélène
机构信息
INSERM, U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
出版信息
Dement Geriatr Cogn Disord. 2016;41(3-4):137-45. doi: 10.1159/000443790. Epub 2016 Feb 25.
BACKGROUND
This study investigates the relationship between psychosocioeconomic precariousness, cognitive decline and risk of developing dementia.
METHODS
The sample consisted of 3,710 subjects aged ≥65 years. Psychosocioeconomic precariousness was assessed with a ratio consisting of 8 self-reported items of poor socioeconomic status and psychosocial vulnerability.
RESULTS
Participants who were considered as precarious (n = 1,444) presented greater cognitive decline (β = -0.07; p = 0.0067) after adjusting for various confounders. They also had a 36% increased risk of developing dementia (hazard ratio 1.36, 95% confidence interval 1.17-1.57; p < 0.0001) over the 25-year follow-up period.
CONCLUSION
Psychosocioeconomic precariousness is associated with greater cognitive decline and increased risk of developing dementia. This relationship can be explained in light of the concept of cognitive reserve and strengthens the need to consider psychosocioeconomic precariousness of elderly individuals in the definition of successful ageing policies.
背景
本研究调查社会经济不稳定状况、认知能力下降与患痴呆症风险之间的关系。
方法
样本包括3710名年龄≥65岁的受试者。社会经济不稳定状况通过一个比率进行评估，该比率由8项自我报告的社会经济地位差和心理社会脆弱性项目组成。
结果
在调整各种混杂因素后，被认为处于不稳定状态的参与者（n = 1444）表现出更大的认知能力下降（β = -0.07；p = 0.0067）。在25年的随访期内，他们患痴呆症的风险也增加了36%（风险比1.36，95%置信区间1.17 - 1.57；p < 0.0001）。
结论
社会经济不稳定状况与更大的认知能力下降以及患痴呆症风险增加有关。这种关系可以根据认知储备的概念来解释，并强化了在成功老龄化政策的定义中考虑老年人社会经济不稳定状况的必要性。
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