驻留血管干细胞的功能状态与血管重塑
Functional states of resident vascular stem cells and vascular remodeling.
作者信息
Leach Desiree F, Nagarkatti Mitzi, Nagarkatti Prakash, Cui Taixing
机构信息
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
出版信息
Front Biol (Beijing). 2015 Oct 1;10(5):387-397. doi: 10.1007/s11515-015-1375-x.
Recent evidence indicates that different types of vascular stem cells (VSCs) reside within the mural layers of arteries and veins. The precise identities of these resident VSCs are still unclear; generally, postnatal vasculature contains multilineage stem cells and vascular cell lineage-specific progenitor/stem cells which may participate in both vascular repair and lesion formation. However, the underlying mechanism remains poorly understood. In this review, we summarize the potential molecular mechanisms, which may control the quiescence and activation of resident VSCs and highlight a notion that the differential states of resident VSCs are directly linked to vascular repair or lesion formation.
最近的证据表明，不同类型的血管干细胞（VSCs）存在于动脉和静脉的壁层中。这些驻留VSCs的确切身份仍不清楚；一般来说，出生后的脉管系统包含多谱系干细胞以及血管细胞谱系特异性祖细胞/干细胞，它们可能参与血管修复和病变形成。然而，其潜在机制仍知之甚少。在本综述中，我们总结了可能控制驻留VSCs静止和激活的潜在分子机制，并强调了一个观点，即驻留VSCs的不同状态与血管修复或病变形成直接相关。
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