尼泊尔西部三级护理医院中艾滋病毒感染者的乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）合并感染情况

Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Co-Infection Among HIV Infected Individuals at Tertiary Care Hospital in Western Nepal.

作者信息

Supram Hosuru Subramanya, Gokhale Shishir, Sathian Brijesh, Bhatta Dharma Raj

机构信息

Department of Microbiology, Manipal College of Medical sciences , Pokhara, Nepal.

Department of Community Medicine, Manipal College of Medical sciences , Pokhara, Nepal.

出版信息

Nepal J Epidemiol. 2015 Jun 1;5(2):488-93. doi: 10.3126/nje.v5i2.12831. eCollection 2015 Jun.

DOI:10.3126/nje.v5i2.12831

PMID:26913208

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4727548/

Abstract

BACKGROUND

The HIV, HBV and HCV viruses are the major public health concern all over the world including Nepal. The aim of the study is to determine the rate of HBV and HCV co-infections in patients with HIV infection.

METHODS

The study cohort included 218 consecutive HIV infected patients who were examined for co-infection with HBV or HCV or both at Manipal teaching hospital, Western Nepal. The demographic data of the subjects was collected retrospectively. The data was analyzed with SPSS software and EPI Info to measure the correlation of variables and infection rates.

RESULTS

In the course of six years study period, a total of 25,708 samples were collected for HIV screening test. The 218 (0.8%) screen test positive for HIV were confirmed as per WHO guidelines. The overall rate of co-infection with HBV and or HCV was 7.3% (16 of 218 patients). Only 7 (3.2% [CI 1.3, 6.5]) were positive for both HIV and HBV infection markers and 9 (4.1% [CI 1.9, 7.7]) were positive for HIV and HCV infection markers. None were positive of all three virus markers.

CONCLUSION

It is advisable to implementregular screening for Hepatitis B Virus and Hepatitis C Virus among all HIV infected individuals and their sexual partners.

摘要

背景

包括尼泊尔在内，艾滋病毒、乙肝病毒和丙肝病毒是全球主要的公共卫生问题。本研究旨在确定艾滋病毒感染患者中乙肝和丙肝合并感染率。

方法

研究队列包括218例连续的艾滋病毒感染患者，这些患者在尼泊尔西部的马尼帕尔教学医院接受了乙肝或丙肝或两者合并感染的检查。回顾性收集受试者的人口统计学数据。使用SPSS软件和EPI Info对数据进行分析，以测量变量之间的相关性和感染率。

结果

在为期六年的研究期间，共收集了25,708份样本进行艾滋病毒筛查检测。根据世界卫生组织指南，218例（0.8%）艾滋病毒筛查呈阳性的患者得到确诊。乙肝和/或丙肝合并感染的总体发生率为7.3%（218例患者中的16例）。只有7例（3.2%[置信区间1.3, 6.5]）艾滋病毒和乙肝感染标志物均呈阳性，9例（4.1%[置信区间1.9, 7.7]）艾滋病毒和丙肝感染标志物呈阳性。没有患者三种病毒标志物均呈阳性。