Stene T, Koppang H S
Scand J Dent Res. 1980 Apr;88(2):96-103. doi: 10.1111/j.1600-0722.1980.tb01200.x.
-0.7 mg/kg VCR was given to nine rats in three experimental groups. Twenty-three hours after VCR injection the animals were injected with 3H-thymidine. The animals were sacrificed 24, 48 and 72 h after the VCR injection, and by comparison with nine control animals similarly injected with sodium chloride solution and nucleotide, it was shown that VCR causes a delayed migration of pulp cells from the proliferative pool and a small but distinct inhibition of the incisal growth of the incisors. The growth inhibition corresponded to the normal growth over a 24-h period in non-VCR-injected animals.
给三个实验组的九只大鼠注射0.7毫克/千克的长春新碱。在注射长春新碱23小时后，给这些动物注射3H-胸腺嘧啶核苷。在注射长春新碱后24、48和72小时处死动物，与同样注射氯化钠溶液和核苷酸的九只对照动物相比，结果显示长春新碱导致牙髓细胞从增殖池的迁移延迟，并对切牙的切端生长有轻微但明显的抑制作用。这种生长抑制相当于未注射长春新碱的动物在24小时内的正常生长情况。
