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内侧前额叶皮质电刺激对健康大鼠和成瘾大鼠被动回避记忆的影响。

The effect of medial prefrontal cortex electrical stimulation on passive avoidance memory in healthy and addict rats.

作者信息

Mehdipour Shima, Alaei Hojjat Allah, Pilehvariyan Ali Asghar

机构信息

Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Basic Sciences, Isfahan Payame Noor University, Isfahan, Iran.

出版信息

Adv Biomed Res. 2015 Nov 30;4:254. doi: 10.4103/2277-9175.170679. eCollection 2015.

DOI:10.4103/2277-9175.170679
PMID:26918236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4746940/
Abstract

BACKGROUND

The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. The mPFC receives strong dopaminergic innervations from ventral tegmental area (VTA) that comprises a portion of the mesolimbic dopaminergic system (MLDS), and sends glutamatergic projections to both the VTA and nucleus accumbens (NAc).

MATERIALS AND METHODS

In this study, male Wister rats weighing 250-350 g were used. The effect of medial prefrontal cortex (mPFC) electrical stimulation with different current intensities (25, 50,100, and 150 μA) in healthy and addicted rats on passive avoidance memory was studied here.

RESULTS

This study showed that 25 and 150 μA had no effect on improving avoidance memory in rats. Current intensities of 50 and 100 μA differ significantly with 25 and 150 μA. The PL of mPFC contributes to memory processing.

CONCLUSIONS

The electrical stimulations of prelimbic with 50 and 100 μA current intensities were improved avoidance memory in addicted rats while learning impairment is caused in healthy rats while the electrical stimulation with these used current intensities.

摘要

背景

内侧前额叶皮质（mPFC）是大脑奖赏系统的一部分，参与学习和记忆等认知功能。mPFC接受来自腹侧被盖区（VTA）的强大多巴胺能神经支配，VTA是中脑边缘多巴胺能系统（MLDS）的一部分，并且向VTA和伏隔核（NAc）发送谷氨酸能投射。

材料与方法

在本研究中，使用体重为250 - 350 g的雄性Wister大鼠。研究了在健康大鼠和成瘾大鼠中，不同电流强度（25、50、100和150 μA）的内侧前额叶皮质（mPFC）电刺激对被动回避记忆的影响。

结果

本研究表明，25和150 μA对改善大鼠的回避记忆没有影响。50和100 μA的电流强度与25和150 μA有显著差异。mPFC的前边缘区（PL）有助于记忆处理。

结论

50和100 μA电流强度的前边缘区电刺激改善了成瘾大鼠的回避记忆，而在健康大鼠中，这些电流强度的电刺激导致学习障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/39962e2fe8c7/ABR-4-254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/0cc43de7e655/ABR-4-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/944b61db3e56/ABR-4-254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/a9e324d0af3e/ABR-4-254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/e1788f259cc8/ABR-4-254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/39962e2fe8c7/ABR-4-254-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/0cc43de7e655/ABR-4-254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/944b61db3e56/ABR-4-254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/a9e324d0af3e/ABR-4-254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/e1788f259cc8/ABR-4-254-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d7e/4746940/39962e2fe8c7/ABR-4-254-g005.jpg

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本文引用的文献

1
Neurocircuitry of addiction.成瘾的神经回路。
Neuropsychopharmacology. 2010 Jan;35(1):217-38. doi: 10.1038/npp.2009.110.
2
Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens.电针 2Hz 抑制大鼠吗啡诱导的条件性位置偏爱：伏核内啡肽的作用。
Neuropharmacology. 2010 Jan;58(1):233-40. doi: 10.1016/j.neuropharm.2009.07.007. Epub 2009 Jul 14.
3
Glutamate transmission in addiction.成瘾中的谷氨酸传递。
使用姜黄素预防大鼠睡眠剥夺引起的内侧前额叶皮质的结构和行为变化。
EXCLI J. 2017 Apr 18;16:510-520. doi: 10.17179/excli2017-139. eCollection 2017.
Neuropharmacology. 2009;56 Suppl 1(Suppl 1):169-73. doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.
4
Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice.内侧前额叶皮质损伤会阻止小鼠获得吗啡诱导的条件性位置偏爱，但不会阻止其恢复。
Neurosci Lett. 2008 Mar 5;433(1):48-53. doi: 10.1016/j.neulet.2007.12.040.
5
Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat.大鼠情绪和认知加工过程中内侧前额叶皮质、海马体和中线丘脑之间的相互作用。
Neuroscience. 2006 Sep 29;142(1):1-20. doi: 10.1016/j.neuroscience.2006.06.027. Epub 2006 Aug 2.
6
Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex.κ阿片类物质选择性地控制投射到前额叶皮质的多巴胺能神经元。
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2938-42. doi: 10.1073/pnas.0511159103. Epub 2006 Feb 13.
7
Ascorbate reduces morphine-induced extracellular DOPAC level in the nucleus accumbens: A microdialysis study in rats.抗坏血酸盐降低伏隔核中吗啡诱导的细胞外3,4-二羟基苯乙酸水平：大鼠微透析研究
Brain Res. 2005 Aug 16;1053(1-2):62-6. doi: 10.1016/j.brainres.2005.06.040.
8
Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats.吗啡降低前扣带回皮质中谷氨酸的细胞外水平：一项对自由活动大鼠的体内微透析研究。
Brain Res. 2005 Apr 8;1040(1-2):191-6. doi: 10.1016/j.brainres.2005.01.072.
9
The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics.大鼠内侧前额叶皮层：基于功能和解剖学特征的背腹区分证据。
Neurosci Biobehav Rev. 2003 Oct;27(6):555-79. doi: 10.1016/j.neubiorev.2003.09.003.
10
Glutamatergic mechanisms in addiction.成瘾中的谷氨酸能机制。
Mol Psychiatry. 2003 Apr;8(4):373-82. doi: 10.1038/sj.mp.4001269.