Chen Wen, Guo Junxia, Zhang Yanzhen, Zhang Jing
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, P.R. China.
Food Funct. 2016 Apr;7(4):1849-63. doi: 10.1039/c5fo01295c.
Metabolic syndrome, a cluster of risk factors for diabetes and cardiovascular disease, has become a very serious public health concern. A number of studies have provided evidence that taurine has an efficient action against metabolic syndrome, which includes reducing triglycerides to prevent obesity, improving insulin resistance to regulate glucose metabolism, lowering cholesterol (especially decreasing VLDL + LDL cholesterol and increasing HDL cholesterol) to prevent diet-induced hypercholesterolemia, and regulating the renin-angiotensin-aldosterone system and the kallikrein-kinin system etc. to reduce blood pressure. This review summarizes the data from in vitro, animal and limited human studies of beneficial effects of taurine on obesity, dyslipidaemia, diabetes mellitus and hypertension, and addresses the possible metabolic and molecular mechanisms of the prevention of metabolic syndrome by taurine.
代谢综合征是糖尿病和心血管疾病的一组危险因素，已成为一个非常严重的公共卫生问题。多项研究已提供证据表明，牛磺酸对代谢综合征具有有效作用，包括降低甘油三酯以预防肥胖、改善胰岛素抵抗以调节葡萄糖代谢、降低胆固醇（特别是降低极低密度脂蛋白 + 低密度脂蛋白胆固醇并增加高密度脂蛋白胆固醇）以预防饮食诱导的高胆固醇血症，以及调节肾素 - 血管紧张素 - 醛固酮系统和激肽释放酶 - 激肽系统等以降低血压。本综述总结了来自体外、动物和有限的人体研究中关于牛磺酸对肥胖、血脂异常、糖尿病和高血压有益作用的数据，并探讨了牛磺酸预防代谢综合征可能的代谢和分子机制。
