Hao Jie, Cheng Kenneth C K, Kruger Laura G, Larsson Lena, Sugai James V, Lahann Joerg, Giannobile William V
Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI, 48109-1078, USA.
Biointerfaces Institute, Department of Materials Science and Engineering, B26-115S NCRC, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA.
Adv Mater. 2016 Apr;28(16):3145-51. doi: 10.1002/adma.201600027. Epub 2016 Feb 25.
Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
分子可以通过化学气相沉积（CVD）涂层策略固定在生物材料上。五氟苯酚酯基团与抗体上的胺侧链反应，这可以选择性地固定腺病毒载体用于生长因子的基因递送。这些载体可以在生物材料的特定区域内产生功能蛋白，以产生用于靶向组织再生的可定制结构。
