Dai Sheng-Jun, Zhang Lei, Xiao Kai, Han Qing-Tong
School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China.
Bioorg Med Chem Lett. 2016 Apr 1;26(7):1750-3. doi: 10.1016/j.bmcl.2016.02.045. Epub 2016 Feb 17.
Three new neo-clerodane diterpenoids, named scutestrigillosins A-C (1-3), were isolated from the whole plant of Scutellaria strigillosa. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, the isolated three new compounds exhibited significant cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7 and HT29), and gave IC50 values in the range 3.5-7.7μM.
从糙毛黄芩全草中分离出三种新的克罗烷二萜类化合物，命名为糙毛黄芩素A - C（1 - 3）。基于详细的物理数据分析确定了它们的化学结构，包括绝对构型。在体外，分离得到的这三种新化合物对四种肿瘤细胞系（HONE - 1、P - 388、MCF7和HT29）表现出显著的细胞毒活性，IC50值在3.5 - 7.7μM范围内。
