半枝莲中两个新的具有细胞毒性的对映-贝壳杉烷二萜类化合物。

Two new cytotoxic ent-clerodane diterpenoids from Scutellaria barbata.

作者信息

Qu Gui-Wu, Yue Xi-Dian, Li Gui-Sheng, Yu Qun-Ying, Dai Sheng-Jun

机构信息

College of Food Science and Technology, Ocean University of China, Qingdao, China.

出版信息

J Asian Nat Prod Res. 2010 Oct;12(10):859-64. doi: 10.1080/10286020.2010.507546.

DOI:10.1080/10286020.2010.507546

PMID:20924899

Abstract

Two new ent-clerodane diterpenoids have been isolated from Scutellaria barbata, and their structures were established by detailed spectroscopic analyses as (13R)-6α,7β-dihydroxy-8β,13-epoxy-11β-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1) and (11E)-6α-acetoxy-7β,8β-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer cell lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC(50) values in the range of 2.5-6.6 μM.

摘要

从半枝莲中分离出两种新的对映-克罗烷二萜类化合物，通过详细的光谱分析确定它们的结构分别为(13R)-6α,7β-二羟基-8β,13-环氧-11β-烟酰氧基-对映-克罗丹-3-烯-15,16-内酯（半枝莲醌D，1）和(11E)-6α-乙酰氧基-7β,8β-二羟基-对映-克罗丹-3,11,13-三烯-15,16-内酯（6-乙酰氧基半枝莲素C，2）。在体外，分离得到的这两种新化合物对三种人类癌细胞系（HONE-1鼻咽癌、KB口腔表皮样癌和HT29结肠癌细胞）显示出显著的细胞毒活性，半数抑制浓度（IC50）值在2.5 - 6.6 μM范围内。