Wang Yunfei, Hou Jiakai, He Dandan, Sun Ming, Zhang Peng, Yu Yonghao, Chen Yiwen
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Trends Genet. 2016 Apr;32(4):211-224. doi: 10.1016/j.tig.2016.02.001. Epub 2016 Feb 24.
Complex diseases, such as cancer, are often associated with aberrant gene expression at both the transcriptional and post-transcriptional level. Over the past several years, competing endogenous RNAs (ceRNAs) have emerged as an important class of post-transcriptional regulators that alter gene expression through a miRNA-mediated mechanism. Recent studies in both solid tumors and hematopoietic malignancies showed that ceRNAs have significant roles in cancer pathogenesis by altering the expression of key tumorigenic or tumor-suppressive genes. Characterizing the identity, function, and mechanism of the ceRNAs will not only further our fundamental understanding of RNA-mediated cancer pathogenesis, but may also shed light on the development of new RNA-based therapeutic strategies for treating cancer.
诸如癌症等复杂疾病通常与转录和转录后水平的异常基因表达相关。在过去几年中，竞争性内源RNA（ceRNA）已成为一类重要的转录后调节因子，其通过miRNA介导的机制改变基因表达。最近在实体瘤和血液系统恶性肿瘤中的研究表明，ceRNA通过改变关键致癌或抑癌基因的表达在癌症发病机制中发挥重要作用。鉴定ceRNA的身份、功能和机制不仅将加深我们对RNA介导的癌症发病机制的基本理解，还可能为开发基于RNA的新型癌症治疗策略提供线索。
