Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Cancer Biol Med. 2021 Feb 15;18(1):1-20. doi: 10.20892/j.issn.2095-3941.2020.0203.
Competing endogenous RNAs (ceRNAs) containing microRNA response elements can competitively interact with microRNA via miRNA response elements, which can combine non-coding RNAs with protein-coding RNAs through complex ceRNA networks. CeRNAs include non-coding RNAs (long non-coding RNAs, circular RNAs, and transcribed pseudogenes) and protein-coding RNAs (mRNAs). Molecular interactions in ceRNA networks can coordinate many biological processes; however, they may also lead to ceRNA network imbalance and thus contribute to cancer occurrence when disturbed. Recent studies indicate that many dysregulated RNAs derived from lung cancer may function as ceRNAs to regulate multitudinous biological functions for lung cancer, including tumor cell proliferation, apoptosis, growth, invasion, migration, and metastasis. This study therefore reviewed the research progress in the field of non-coding and protein-coding RNAs as ceRNAs in lung cancer, and highlighted validated ceRNAs involved in biological lung cancer functions. Furthermore, the roles of ceRNAs as novel prognostic and diagnostic biomarkers were also discussed. Interpreting the involvement of ceRNAs networks in lung cancer will provide new insight into cancer pathogenesis and treatment strategies.
竞争性内源 RNA（ceRNA）含有 microRNA 反应元件，可通过 miRNA 反应元件与 microRNA 进行竞争性相互作用，通过复杂的 ceRNA 网络将非编码 RNA 与蛋白质编码 RNA 结合起来。ceRNA 包括非编码 RNA（长非编码 RNA、环状 RNA 和转录假基因）和蛋白质编码 RNA（mRNA）。ceRNA 网络中的分子相互作用可以协调许多生物学过程；然而，当受到干扰时，它们也可能导致 ceRNA 网络失衡，从而导致癌症的发生。最近的研究表明，许多源自肺癌的失调 RNA 可能作为 ceRNA 发挥作用，调节肺癌的多种生物学功能，包括肿瘤细胞增殖、凋亡、生长、侵袭、迁移和转移。因此，本研究综述了非编码和蛋白质编码 RNA 作为 ceRNA 在肺癌中的研究进展，并强调了参与生物学肺癌功能的经过验证的 ceRNA。此外，还讨论了 ceRNA 作为新型预后和诊断生物标志物的作用。解释 ceRNA 网络在肺癌中的作用将为癌症发病机制和治疗策略提供新的见解。
