Komoda Toshikazu, Saeki Naoko, Koseki Yoshitaka, Kiyota Hiromasa
School of Food, Agricultural, and Environmental Sciences, Miyagi University.
J Gen Appl Microbiol. 2016;62(1):1-6. doi: 10.2323/jgam.62.1.
We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).
我们从链霉菌属的一种培养物中鉴定出两种新的自由基清除剂，12T061A（1，C19H20O7）和12T061C（2，C20H22O7）。光谱分析表明这些化合物是新的聚酮色菌素家族化合物。化合物1和2分别具有自由基清除活性，其半数有效剂量（ED50）为370 μM和18 μM。此外，1在HepG2细胞中显示出肿瘤细胞生长抑制活性（半数抑制浓度：3.6 μM）；然而，2未显示出抑制活性（半数抑制浓度：>100 μM）。
