a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , P.R. China.
Nat Prod Res. 2014;28(4):265-7. doi: 10.1080/14786419.2013.830219. Epub 2013 Aug 25.
Four known compounds had been isolated from the Streptomyces sp. YIM66017, and their structures were elucidated by spectral analysis as 2,6-dimethoxy terephthalic acid (1), yangjinhualine A (2), α-hydroxyacetovanillone (3) and cyclo(Gly-Trp) (4). Compound 1 was isolated from natural resources for the first time, and compounds 2-4 were isolated from streptomycetes for the first time. The 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity assays showed that 1 showed higher activity than rutin with IC50 of 4.61 μg/mL and 2 showed the activity with IC50 of 57.12 μg/mL.
从链霉菌 sp. YIM66017 中分离得到 4 种已知化合物，并通过光谱分析将其结构解析为 2,6-二甲氧基对苯二甲酸（1）、yangjinhualine A（2）、α-羟基乙酰香草酮（3）和环（Gly-Trp）（4）。化合物 1 为首次从天然资源中分离得到，化合物 2-4 为首次从链霉菌中分离得到。2,2-二苯基-1-苦基肼自由基清除活性测定表明，化合物 1 的活性高于芦丁，IC50 为 4.61μg/mL，化合物 2 的活性为 57.12μg/mL。
