Komoda Toshikazu, Tamiya Yuta, Nishikawa Masazumi
School of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai, Miyagi, Japan.
Biosci Biotechnol Biochem. 2011;75(10):2056-8. doi: 10.1271/bbb.110384. Epub 2011 Oct 7.
We identified a new radical scavenger, 10T024A (C(15)H(12)N(2)O(4)), from a culture of the Streptomyces sp. Spectroscopic elucidation indicated that this compound is a new phenazine derivative. 10T024A showed radical-scavenging activity with an ED(50) of 125 µM. Moreover, it showed prostaglandin D(2) (PGD(2)) and leukotriene B(4) (LTB(4)) release suppressive activity in rat basophilic leukemia (RBL-2H3) cells, at IC(50): 8 µM and 10 µM respectively.
我们从链霉菌属的一种培养物中鉴定出一种新的自由基清除剂10T024A（C₁₅H₁₂N₂O₄）。光谱解析表明该化合物是一种新的吩嗪衍生物。10T024A表现出自由基清除活性，半数有效剂量（ED₅₀）为125 μM。此外，它在大鼠嗜碱性白血病（RBL - 2H3）细胞中表现出前列腺素D₂（PGD₂）和白三烯B₄（LTB₄）释放抑制活性，半数抑制浓度（IC₅₀）分别为8 μM和10 μM。
