古老草药圣罗勒对四氯化碳诱导的大鼠肝损伤的抗氧化活性
Antioxidant Activity of The Ancient Herb, Holy Basil in CCl-Induced Liver Injury in Rats.
作者信息
Ponnusam Yuvaraj, Louis Therasilin, Madhavachandran V, Kumar Suresh, Thoprani Neelam, Hamblin Michael R, Lakshmanan Shanmugamurthy
机构信息
Department of Experimental Pharmacology, Research and Development Unit, Nagarjuna Herbal Concentrates Ltd, Thodupuzha, Kerala, India.
CareKeralam Ltd, Koratty, Thrissur Dt, Kerala, India.
出版信息
Ayurvedic. 2015 Nov;2(2):34-38. doi: 10.14259/av.v2i2.176.
An herbal preparation called "holy basil plus herbal powder" (HBPP) containing and was investigated as an antioxidant and hepatoprotect agent. The antioxidant activity of HBPP was investigated in rats with liver injury induced by oral administration of carbon tetrachloride:olive oil (1:1). HBPP was administered orally at 500 mg/kg daily for 7 days before. HBPP exhibited statistically significant antioxidant activity, as shown by increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO). HBPP performed equally well as silymarin, a well-established antioxidant preparation used to protect against liver injury.
一种名为“圣罗勒加草药粉”（HBPP）的草药制剂含有[具体成分未给出]，被作为一种抗氧化剂和肝脏保护剂进行了研究。在经口给予四氯化碳：橄榄油（1:1）诱导肝损伤的大鼠中研究了HBPP的抗氧化活性。在给予四氯化碳之前，每天以500毫克/千克的剂量口服HBPP，持续7天。HBPP表现出具有统计学意义的抗氧化活性，表现为谷胱甘肽过氧化物酶（GPX）、谷胱甘肽S -转移酶（GST）、谷胱甘肽还原酶（GRD）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）水平升高，脂质过氧化（LPO）水平降低。HBPP的效果与水飞蓟宾相当，水飞蓟宾是一种用于预防肝损伤的成熟抗氧化制剂。
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