Arlow Sophie I, Hartwig John F
Department of Chemistry, University of California, Berkeley, CA, 94720, USA.
Angew Chem Int Ed Engl. 2016 Mar 24;55(14):4567-72. doi: 10.1002/anie.201600105. Epub 2016 Mar 1.
A copper-catalyzed coupling of aryl, heteroaryl, and vinyl iodides with α-silyldifluoroamides is reported. The reaction forms α,α-difluoro-α-aryl amides from electron-rich, electron-poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can be transformed further to provide access to a diverse array of difluoroalkylarenes, including compounds of potential biological interest.
据报道，铜催化芳基碘化物、杂芳基碘化物和乙烯基碘化物与α-硅基二氟酰胺发生偶联反应。该反应能以高产率从富电子、缺电子和空间位阻较大的芳基碘化物生成α,α-二氟-α-芳基酰胺，并且能耐受多种官能团。芳基二氟酰胺产物可进一步转化，从而获得各种各样的二氟烷基芳烃，包括具有潜在生物学意义的化合物。
