Maleki Farajollah, Abdi Soghra, Davodian Elaham, Haghani Karimeh, Bakhtiyari Salar
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Osong Public Health Res Perspect. 2015 Oct;6(5):283-7. doi: 10.1016/j.phrp.2015.10.001. Epub 2015 Oct 23.
Aflatoxins as a highly toxic group of mycotoxins are present in the environment and foodstuff. These have been reported to cause serious health problems in humans. Since aflatoxin M1 (AFM1) is excreted into breast milk, investigating the exposure of infants to AFM1 is of special concern.
In the present study, breast milk samples were collected from 85 lactating mothers in Ilam province, Iran, and the levels of AFM1 were analyzed using the enzyme-linked immunosorbent assay-based technique. AFM1 was detected in breast milk of all lactating women. The mean contamination level was 5.91 ± 2.031 ng/L, ranging from 2 ng/L to 10 ng/L.
Multiple regression analysis indicated no significant associations of consumption of milk and dairy products, meat, fish, legumes, grain products, fruits, and nuts with the concentration of AFM1 in breast milk. Furthermore, no significant association was observed between AFM1 concentration and anthropometric data of infants.
In western parts of Iran, lactating mothers and their infants could be at risk of aflatoxin B1 and AFM1 exposure, respectively. Therefore, in Iran, the evaluation of AFM1 in human breast milk as a biomarker for postnatal exposure of infants to this carcinogen requires more attention in different regions and various seasons.
黄曲霉毒素作为一组剧毒的霉菌毒素存在于环境和食品中。据报道，这些毒素会给人类带来严重的健康问题。由于黄曲霉毒素M1（AFM1）会排泄到母乳中，因此调查婴儿对AFM1的暴露情况备受关注。
在本研究中，从伊朗伊拉姆省的85名哺乳期母亲中采集了母乳样本，并使用基于酶联免疫吸附测定的技术分析了AFM1的含量。在所有哺乳期妇女的母乳中均检测到了AFM1。平均污染水平为5.91±2.031纳克/升，范围在2纳克/升至10纳克/升之间。
多元回归分析表明，牛奶及奶制品、肉类、鱼类、豆类、谷物制品、水果和坚果的摄入量与母乳中AFM1的浓度之间无显著关联。此外，未观察到AFM1浓度与婴儿人体测量数据之间存在显著关联。
在伊朗西部，哺乳期母亲及其婴儿可能分别面临黄曲霉毒素B1和AFM1暴露的风险。因此，在伊朗，将母乳中的AFM1作为婴儿出生后接触这种致癌物的生物标志物进行评估，在不同地区和不同季节都需要更多关注。
