1 German Sport University Cologne, Germany.
2 University of Cologne, Germany.
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419832358. doi: 10.1177/1534735419832358.
In patients with hematological malignancies, exercise is studied as a supportive measure with potential benefits on therapy and disease-related side effects. However, clinical trials have not yet integrated people with Down syndrome (DS), although this disability is associated with an increased risk for hematological malignancies. Therefore, we examined safety and feasibility of a mixed-modality exercise intervention in a male with DS undergoing high-dose chemotherapy for acute lymphoblastic leukemia. Furthermore, physical capacity and fatigue were assessed. Exercise sessions took place 3 times/wk over a 5-week period. Adherence to the exercise program was 100%, and no serious adverse events occurred. In contrast to the training sessions, applied endurance testing was not feasible. Furthermore, maintenance of fatigue level was observed. In conclusion, cancer patients with DS suffering from leukemia should not be excluded from physical activity or exercise programs.
在血液系统恶性肿瘤患者中，运动被作为一种支持性治疗措施进行研究，其具有改善治疗效果和减轻疾病相关副作用的潜在益处。然而，目前的临床试验尚未将唐氏综合征（Down syndrome，DS）患者纳入其中，尽管这种残疾与血液系统恶性肿瘤的风险增加相关。因此，我们研究了一名男性 DS 患者在接受高强度化疗治疗急性淋巴细胞白血病时，混合模式的运动干预措施的安全性和可行性。此外，我们还评估了患者的身体能力和疲劳情况。运动课程每周进行 3 次，持续 5 周。该患者的运动依从性为 100%，且未发生严重不良事件。与训练课程不同的是，应用耐力测试并不适用。此外，我们观察到患者的疲劳水平得到了维持。总之，患有白血病的 DS 癌症患者不应被排除在体育活动或运动方案之外。
