Gray Glenda E, Laher Fatima, Doherty Tanya, Abdool Karim Salim, Hammer Scott, Mascola John, Beyrer Chris, Corey Larry
South African Medical Research Council, Cape Town, South Africa.
Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
PLoS Biol. 2016 Mar 2;14(3):e1002372. doi: 10.1371/journal.pbio.1002372. eCollection 2016 Mar.
In the last 15 years, antiretroviral therapy (ART) has been the most globally impactful life-saving development of medical research. Antiretrovirals (ARVs) are used with great success for both the treatment and prevention of HIV infection. Despite these remarkable advances, this epidemic grows relentlessly worldwide. Over 2.1 million new infections occur each year, two-thirds in women and 240,000 in children. The widespread elimination of HIV will require the development of new, more potent prevention tools. Such efforts are imperative on a global scale. However, it must also be recognised that true containment of the epidemic requires the development and widespread implementation of a scientific advancement that has eluded us to date--a highly effective vaccine. Striving for such medical advances is what is required to achieve the end of AIDS.
在过去15年里，抗逆转录病毒疗法（ART）一直是医学研究领域在全球范围内最具影响力的挽救生命的进展。抗逆转录病毒药物（ARVs）在治疗和预防HIV感染方面都取得了巨大成功。尽管取得了这些显著进展，但这一流行病在全球范围内仍在无情蔓延。每年有超过210万新感染病例，其中三分之二是女性，24万是儿童。要广泛消除HIV，就需要开发新的、更有效的预防工具。在全球范围内，这样的努力势在必行。然而，还必须认识到，真正控制这一流行病需要开发并广泛实施一项至今仍未实现的科学进步——一种高效疫苗。为实现艾滋病终结的目标，就需要努力推动这样的医学进步。
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