Fahim Ayesha, Ilyas Muhammad Sharjeel, Jafari Fahim Haider, Farzana Fauzia
Post Graduate Medical Institute, Lahore, Pakistan.
Azra Naheed Medical College, Lahore, Pakistan.
J Oral Biol Craniofac Res. 2016 Jan-Apr;6(1):49-53. doi: 10.1016/j.jobcr.2015.08.005. Epub 2015 Sep 2.
Carbonated drinks are the second most consumed non-alcoholic beverages in the world after tea. The effects of these drinks on hard tissues and vital organs of the body have been proved beyond doubt. This study, however, explains the effect of these drinks on wound healing of oral epithelium.
Thirty-six male Wistar rats were considered for the study. A circular wound of 3.0 mm was created on the buccal mucosa of all animals and they were divided into two groups. Animals in group 1 were fed with chow pellet and water, while those in group 2 were fed with a commercially available carbonated drink instead of water. Six animals from each group were euthanized at 0, 7, and 21 days. Wound site was histologically assessed for differences in thickness and characteristics of the regenerating epithelium between two groups.
There was a marked difference in the healing pattern between the two groups. Animals in group 1 showed a normal healing pattern at the end of day 21. In the group 2, the regenerated epithelium showed hyperplasia and hyperkeratosis along with acanthosis at the end of the experiment with a subsequent delayed inflammatory reaction at day 21.
Consumption of carbonated drinks can disrupt oral wound healing. The contents in carbonated drinks have a proinflammatory action on the soft tissue. Results suggest that epithelial changes seen in experimental group 2 could be a result of constant irritation by the acidic and fizzy nature of carbonated drinks.
碳酸饮料是世界上消费量仅次于茶的非酒精饮料。这些饮料对人体硬组织和重要器官的影响已被确凿证实。然而，本研究解释了这些饮料对口腔上皮伤口愈合的影响。
本研究选用36只雄性Wistar大鼠。在所有动物的颊黏膜上制造一个3.0毫米的圆形伤口，并将它们分为两组。第1组动物喂食普通饲料颗粒和水，而第2组动物用市售碳酸饮料代替水进行喂食。每组在第0、7和21天各安乐死6只动物。对伤口部位进行组织学评估，以比较两组再生上皮厚度和特征的差异。
两组的愈合模式存在显著差异。第1组动物在第21天结束时显示出正常的愈合模式。在第2组中，实验结束时再生上皮出现增生、角化过度以及棘层增厚，随后在第21天出现延迟性炎症反应。
饮用碳酸饮料会干扰口腔伤口愈合。碳酸饮料中的成分对软组织有促炎作用。结果表明，第2组实验中观察到的上皮变化可能是碳酸饮料的酸性和气泡性质持续刺激的结果。
