肿瘤促进剂可抑制培养的小鼠红白血病细胞的自发分化和诱导分化。
Tumor promoters inhibit spontaneous and induced differentiation of murine erythroleukemia cells in culture.
作者信息
Yamasaki H, Fibach E, Nudel U, Weinstein I B, Rifkind R A, Marks P A
出版信息
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3451-5. doi: 10.1073/pnas.74.8.3451.
Abstract
Addition of the potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), to murine erythroleukemia cell lines in suspension cultures inhibited both spontaneous differentiation and differentiation induced by hexamethylene bisacetamide (HMBA), dimethyl sulfoxide, or butyric acid. Inhibition was unrelated to cytotoxicity and was reversible. When several plant diterpenes were tested, there was a positive correlation between tumor-promoting activity and inhibition of differentiation. TPA inhibited HMBA-induced differentiation only if added prior to the time of commitment to differentiation, as assayed by scoring for differentiation after transfer of cells from HMBA to fresh medium without HMBA. TPA-mediated inhibition of differentiation was associated with a decrease in globin mRNA accumulation.
摘要
在悬浮培养的小鼠红白血病细胞系中添加强效肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA），可抑制自发分化以及由六亚甲基双乙酰胺（HMBA）、二甲基亚砜或丁酸诱导的分化。抑制作用与细胞毒性无关且是可逆的。当测试几种植物二萜时，肿瘤促进活性与分化抑制之间存在正相关。只有在通过将细胞从含HMBA的培养基转移至不含HMBA的新鲜培养基后对分化进行评分来测定的、细胞开始分化之前添加TPA，它才会抑制HMBA诱导的分化。TPA介导的分化抑制与珠蛋白mRNA积累的减少有关。
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