Luder Kerstin, Kulkarni Ketav, Lee Huey Wen, Widdop Robert E, Del Borgo Mark P, Aguilar Marie-Isabel
Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia.
Department of Pharmacology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia.
Chem Commun (Camb). 2016 Mar 25;52(24):4549-52. doi: 10.1039/c6cc00247a.
A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.
一种控制细胞生长和分化的常用策略是使用自组装肽作为生物材料。在本研究中，我们用细胞粘附信号IKVAV和RGD修饰超短螺旋N-乙酰化β-三肽，这些肽会自发自组装形成具有多种信号的纳米纤维，并形成一种支持细胞生长的生物支架。
