Angstmann C N, Henry B I, McGann A V
School of Mathematics and Statistics, UNSW Australia, Sydney, 2052, Australia.
Bull Math Biol. 2016 Mar;78(3):468-99. doi: 10.1007/s11538-016-0151-7. Epub 2016 Mar 3.
Over the past several decades, there has been a proliferation of epidemiological models with ordinary derivatives replaced by fractional derivatives in an ad hoc manner. These models may be mathematically interesting, but their relevance is uncertain. Here we develop an SIR model for an epidemic, including vital dynamics, from an underlying stochastic process. We show how fractional differential operators arise naturally in these models whenever the recovery time from the disease is power-law distributed. This can provide a model for a chronic disease process where individuals who are infected for a long time are unlikely to recover. The fractional order recovery model is shown to be consistent with the Kermack-McKendrick age-structured SIR model, and it reduces to the Hethcote-Tudor integral equation SIR model. The derivation from a stochastic process is extended to discrete time, providing a stable numerical method for solving the model equations. We have carried out simulations of the fractional order recovery model showing convergence to equilibrium states. The number of infecteds in the endemic equilibrium state increases as the fractional order of the derivative tends to zero.
在过去几十年中,出现了大量流行病学模型,其中普通导数被以一种临时的方式替换为分数阶导数。这些模型在数学上可能很有趣,但其相关性尚不确定。在此,我们从一个潜在的随机过程出发,为一种流行病开发了一个包含生命动力学的SIR模型。我们展示了只要疾病的恢复时间服从幂律分布,分数阶微分算子如何在这些模型中自然出现。这可以为一种慢性病过程提供一个模型,在该过程中,长时间感染的个体不太可能康复。分数阶恢复模型被证明与Kermack - McKendrick年龄结构的SIR模型一致,并且它简化为Hethcote - Tudor积分方程SIR模型。从随机过程的推导被扩展到离散时间,为求解模型方程提供了一种稳定的数值方法。我们对分数阶恢复模型进行了模拟,显示其收敛到平衡态。在地方病平衡态下,感染个体的数量随着导数的分数阶趋于零而增加。