Watterson Daniel, Modhiran Naphak, Young Paul R
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Antiviral Res. 2016 Jun;130:7-18. doi: 10.1016/j.antiviral.2016.02.014. Epub 2016 Mar 2.
The flavivirus non-structural protein, NS1, is an unusual viral gene product. Despite the recent unveiling of its atomic structure (Akey et al., 2014), and a growing list of host molecules with which it has been found associated, the primary function of NS1 remains elusive. It assumes many diverse roles including direct participation in the flaviviral replication complex and virion maturation. In its secreted form it is a hexameric lipoparticle that is involved in systemic immune and endothelial cell modulation. In this review we highlight recent advances in elucidating the molecular mechanisms underpinning NS1 function and present the current state of play and some future prospects for NS1 targeted antiviral strategies. This article forms part of a symposium on flavivirus drug discovery in Antiviral Research.
黄病毒非结构蛋白NS1是一种独特的病毒基因产物。尽管其原子结构最近已被揭示（Akey等人，2014年），并且已发现与之相关的宿主分子清单不断增加，但NS1的主要功能仍然难以捉摸。它具有许多不同的作用，包括直接参与黄病毒复制复合体和病毒粒子成熟。以其分泌形式存在时，它是一种六聚体脂颗粒，参与全身免疫和内皮细胞调节。在本综述中，我们重点介绍了阐明NS1功能基础的分子机制方面的最新进展，并介绍了NS1靶向抗病毒策略的当前进展情况和一些未来前景。本文是《抗病毒研究》中黄病毒药物发现研讨会的一部分。
