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Gut microbiota impact on stroke outcome: Fad or fact?肠道微生物群对中风预后的影响：时尚还是事实？
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Breaking down the gut microbiome composition in multiple sclerosis.解析多发性硬化症中的肠道微生物组成。
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Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.共生微生物群通过调节肠道γδ T细胞影响缺血性中风的预后。
Nat Med. 2016 May;22(5):516-23. doi: 10.1038/nm.4068. Epub 2016 Mar 28.
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Microbiota-gut-brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers.微生物群-肠-脑轴：肠道微生物及其代谢物与宿主上皮屏障的相互作用。
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Functional Classification of the Gut Microbiota: The Key to Cracking the Microbiota Composition Code: Functional classifications of the gut microbiota reveal previously hidden contributions of indigenous gut bacteria to human health and disease.肠道微生物群的功能分类：破解微生物组组成密码的关键：肠道微生物群的功能分类揭示了本土肠道细菌对人类健康和疾病的先前隐藏贡献。
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Gut microbiota biomodulators, when the stork comes by the scalpel.当鹳鸟借助手术刀降临之时，肠道微生物群生物调节剂。 （此句翻译出来语义较奇特，可能原文表述存在一些不常见或有误的地方，但按照要求准确翻译了）
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[Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury in rats by inhibiting ferroptosis through the gut-brain axis and the Nrf2/HO-1 signaling pathway].[电针预处理通过肠-脑轴和Nrf2/HO-1信号通路抑制铁死亡减轻大鼠脑缺血再灌注损伤]
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The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target.缺血性卒中中的肠-脑轴：其在病理学中的相关性及作为治疗靶点的意义。
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Front Rehabil Sci. 2022 Oct 26;3:1017180. doi: 10.3389/fresc.2022.1017180. eCollection 2022.
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Effect of Dihuang Yinzi on Inflammatory Response in Cerebral Ischemia-Reperfusion Model Rats by Regulating Gut Microbiota.地黄引子通过调节肠道微生物群对脑缺血再灌注模型大鼠炎症反应的影响。
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Long-term modification of gut microbiota by broad-spectrum antibiotics improves stroke outcome in rats.广谱抗生素长期调节肠道微生物群可改善大鼠中风的预后。
Stroke Vasc Neurol. 2022 Oct;7(5):381-389. doi: 10.1136/svn-2021-001231. Epub 2022 May 16.
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Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome.衰老的微生物群-肠-脑轴与中风风险和结局。
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Protection against Neurological Symptoms by Consuming Corn Silk Water Extract in Artery-Occluded Gerbils with Reducing Oxidative Stress, Inflammation, and Post-Stroke Hyperglycemia through the Gut-Brain Axis.通过肠道-脑轴减轻氧化应激、炎症和中风后高血糖，饮用玉米须水提取物对动脉闭塞沙鼠神经症状的保护作用。
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本文引用的文献

1
The human gut virome: a multifaceted majority.人类肠道病毒组：一个多面的主体。
Front Microbiol. 2015 Sep 11;6:918. doi: 10.3389/fmicb.2015.00918. eCollection 2015.
2
Host genetic variation impacts microbiome composition across human body sites.宿主基因变异会影响人体各部位的微生物组组成。
Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
3
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design.小鼠肠道微生物群的异质性：优化实验设计的指南
FEMS Microbiol Rev. 2016 Jan;40(1):117-32. doi: 10.1093/femsre/fuv036. Epub 2015 Aug 30.
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The human gut microbiota and virome: Potential therapeutic implications.人类肠道微生物群与病毒组：潜在的治疗意义。
Dig Liver Dis. 2015 Dec;47(12):1007-12. doi: 10.1016/j.dld.2015.07.008. Epub 2015 Jul 18.
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Peripheral aetiopathogenic drivers and mediators of Parkinson's disease and co-morbidities: role of gastrointestinal microbiota.帕金森病及其合并症的外周病因驱动因素和介质：胃肠道微生物群的作用
J Neurovirol. 2016 Feb;22(1):22-32. doi: 10.1007/s13365-015-0357-8. Epub 2015 Jun 20.
6
Host microbiota constantly control maturation and function of microglia in the CNS.宿主微生物群持续控制中枢神经系统中小胶质细胞的成熟和功能。
Nat Neurosci. 2015 Jul;18(7):965-77. doi: 10.1038/nn.4030. Epub 2015 Jun 1.
7
Under-detection of endospore-forming Firmicutes in metagenomic data.宏基因组数据中形成芽孢的厚壁菌门的检测不足。
Comput Struct Biotechnol J. 2015 Apr 25;13:299-306. doi: 10.1016/j.csbj.2015.04.002. eCollection 2015.
8
Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.小鼠青春期早期肠道微生物群耗竭：对大脑和行为的影响。
Brain Behav Immun. 2015 Aug;48:165-73. doi: 10.1016/j.bbi.2015.04.004. Epub 2015 Apr 10.
9
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.来自肠道微生物群的本土细菌调节宿主血清素的生物合成。
Cell. 2015 Apr 9;161(2):264-76. doi: 10.1016/j.cell.2015.02.047.
10
Gut/brain axis and the microbiota.肠-脑轴与微生物群
J Clin Invest. 2015 Mar 2;125(3):926-38. doi: 10.1172/JCI76304. Epub 2015 Feb 17.

肠道微生物群对中风预后的影响：时尚还是事实？

Gut microbiota impact on stroke outcome: Fad or fact?

作者信息

Winek Katarzyna, Meisel Andreas, Dirnagl Ulrich

机构信息

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany NeuroCure Clinical Research, Charité - Universitätsmedizin Berlin, Berlin, Germany Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

出版信息

J Cereb Blood Flow Metab. 2016 May;36(5):891-8. doi: 10.1177/0271678X16636890. Epub 2016 Mar 4.

DOI:10.1177/0271678X16636890
PMID:26945017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4853845/
Abstract

Microbiota and its contribution to brain function and diseases has become a hot topic in neuroscience. We discuss the emerging role of commensal bacteria in the course of stroke. Further, we review potential pitfalls in microbiota research and their impact on how we interpret the available evidence, emerging results, and on how we design future studies.

摘要

微生物群及其对脑功能和疾病的影响已成为神经科学领域的一个热门话题。我们讨论共生细菌在中风过程中所起的新作用。此外，我们还综述了微生物群研究中潜在的陷阱，以及它们对我们如何解读现有证据、新出现的结果，以及对我们如何设计未来研究的影响。