减少青春期女孩个人护理产品中的邻苯二甲酸盐、对羟基苯甲酸酯和苯酚暴露：HERMOSA干预研究的结果。
Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study.
作者信息
Harley Kim G, Kogut Katherine, Madrigal Daniel S, Cardenas Maritza, Vera Irene A, Meza-Alfaro Gonzalo, She Jianwen, Gavin Qi, Zahedi Rana, Bradman Asa, Eskenazi Brenda, Parra Kimberly L
机构信息
Center for Environmental Research and Children's Health (CERCH), University of California, Berkeley, Berkeley, California, USA.
出版信息
Environ Health Perspect. 2016 Oct;124(10):1600-1607. doi: 10.1289/ehp.1510514. Epub 2016 Mar 7.
BACKGROUND
Personal care products are a source of exposure to potentially endocrine-disrupting chemicals such as phthalates, parabens, triclosan, and benzophenone-3 (BP-3) for adolescent girls.
METHODS
We enrolled 100 Latina girls in a youth-led, community-based participatory research intervention study to determine whether using personal care products whose labels stated they did not contain these chemicals for 3 days could lower urinary concentrations. Pre- and postintervention urine samples were analyzed for phthalate metabolites, parabens, triclosan, and BP-3 using high-performance liquid chromatography/tandem mass spectrometry.
RESULTS
Urinary concentrations of mono-ethyl phthalate (MEP) decreased by 27.4% (95% CI: -39.3, -13.2) on average over the 3-day intervention; no significant changes were seen in urinary concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl phthalate (MiBP). Methyl and propyl paraben concentrations decreased by 43.9% (95% CI: -61.3, -18.8) and 45.4% (95% CI: -63.7, -17.9), respectively. Unexpectedly, concentrations of ethyl and butyl paraben concentrations increased, although concentrations were low overall and not detected in almost half the samples. Triclosan concentrations decreased by 35.7% (95% CI: -53.3, -11.6), and BP-3 concentrations decreased by 36.0% (95% CI: -51.0, -16.4).
DISCUSSION
This study demonstrates that techniques available to consumers, such as choosing personal care products that are labeled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine-disrupting chemicals. Involving youth in the design and implementation of the study was key to recruitment, retention, compliance, and acceptability of the intervention.
CITATION
Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. 2016. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environ Health Perspect 124:1600-1607; http://dx.doi.org/10.1289/ehp.1510514.
背景
个人护理产品是青春期女孩接触潜在内分泌干扰化学物质的来源，如邻苯二甲酸盐、对羟基苯甲酸酯、三氯生和二苯甲酮 - 3（BP - 3）。
方法
我们招募了100名拉丁裔女孩参与一项由青少年主导、基于社区的参与性研究干预项目，以确定使用标签注明不含这些化学物质的个人护理产品3天是否能降低尿液中的浓度。干预前后的尿液样本采用高效液相色谱/串联质谱法分析邻苯二甲酸酯代谢物、对羟基苯甲酸酯、三氯生和BP - 3。
结果
在为期3天的干预期间，尿中邻苯二甲酸单乙酯（MEP）浓度平均下降了27.4%（95%置信区间：-39.3，-13.2）；邻苯二甲酸单丁酯（MnBP）和邻苯二甲酸单异丁酯（MiBP）的尿液浓度未见显著变化。对羟基苯甲酸甲酯和丙酯浓度分别下降了43.9%（95%置信区间：-61.3，-18.8）和45.4%（95%置信区间：-63.7，-17.9）。出乎意料的是，对羟基苯甲酸乙酯和丁酯的浓度有所上升，尽管总体浓度较低，且几乎一半的样本中未检测到。三氯生浓度下降了35.7%（95%置信区间：-53.3，-11.6），BP - 3浓度下降了36.0%（95%置信区间：-51.0，-16.4）。
讨论
本研究表明，消费者可采用的一些方法，如选择标签注明不含邻苯二甲酸盐、对羟基苯甲酸酯、三氯生和BP - 3的个人护理产品，可减少个人接触可能的内分泌干扰化学物质。让青少年参与研究的设计和实施是干预措施招募、留存、依从性和可接受性的关键。
引用文献
Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza - Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. 2016. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environ Health Perspect 124:1600 - 1607; http://dx.doi.org/10.1289/ehp.1510514.
Zotero 插件