Abdalla Mona Mohamed Ibrahim, Choo Soon Siew
Human Biology Department, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.
Physiology Department, Faculty of Medicine, MAHSA University, Kuala Lumpur, Malaysia.
Eur Endocrinol. 2020 Apr;16(1):49-53. doi: 10.17925/EE.2020.16.1.49. Epub 2020 Feb 28.
The study aimed to measure salivary ghrelin levels in healthy adult males and investigate their association with age, weight, height, total as well as regional body fat and muscle mass. The study also aimed to investigate the relative contribution of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) in predicting salivary ghrelin levels in the studied groups.
A sample of young adult males was divided into underweight, normal weight, overweight, and obese groups, according to their BMI. Standardised methods were used to measure height, WC and HC. Total body fat, visceral fat, subcutaneous fat, total and regional muscle mass were assessed by bioelectrical impedance technique utilising Karada scan. Salivary ghrelin concentrations were assessed using enzyme-linked immunosorbent assay.
A total of 90 adult males were included in the analysis (underweight n=9, normal weight n=41, overweight n=22, and obese n=18). One-way ANOVA test revealed significant differences among the groups in all of the variables except height and salivary ghrelin levels. Multiple linear regression revealed a significant association between salivary ghrelin levels with total fat, subcutaneous fat, visceral fat and muscle mass in the obese group. The analysis also revealed that BMI, WC, HC, WHR and WHtR were reliable predictors for salivary ghrelin levels in the obese group but not in other groups.
Anthropometric measures can be used as predictors for salivary ghrelin levels in healthy obese adults. However, they are poor predictors for salivary ghrelin levels in healthy lean, normal and overweight adults.
本研究旨在测量健康成年男性的唾液胃饥饿素水平，并调查其与年龄、体重、身高、全身及局部体脂和肌肉量的关系。本研究还旨在调查体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比（WHR）和腰高比（WHtR）在预测研究组唾液胃饥饿素水平方面的相对贡献。
根据BMI将年轻成年男性样本分为体重过轻、正常体重、超重和肥胖组。采用标准化方法测量身高、WC和HC。利用人体成分分析仪通过生物电阻抗技术评估全身脂肪、内脏脂肪、皮下脂肪、全身及局部肌肉量。采用酶联免疫吸附测定法评估唾液胃饥饿素浓度。
共有90名成年男性纳入分析（体重过轻n = 9，正常体重n = 41，超重n = 22，肥胖n = 18）。单因素方差分析显示，除身高和唾液胃饥饿素水平外，所有变量在各组间均存在显著差异。多元线性回归显示，肥胖组中唾液胃饥饿素水平与总脂肪、皮下脂肪、内脏脂肪和肌肉量之间存在显著关联。分析还显示，BMI、WC、HC、WHR和WHtR是肥胖组唾液胃饥饿素水平的可靠预测指标，但在其他组中并非如此。
人体测量指标可作为健康肥胖成年人唾液胃饥饿素水平的预测指标。然而，它们对健康瘦人、正常体重和超重成年人的唾液胃饥饿素水平预测效果不佳。
