Urs Raksha, Lloyd Harriet O, Reinstein Dan Z, Silverman Ronald H
From the Department of Ophthalmology (Urs, Lloyd, Reinstein, Silverman), Columbia University Medical Center, and F.L. Lizzi Center for Biomedical Engineering (Silverman), Riverside Research, New York, New York, USA; London Vision Clinic (Reinstein), London, United Kingdom; Centre Hospitalier National d'Ophtalmologie (Reinstein), Paris, France.
From the Department of Ophthalmology (Urs, Lloyd, Reinstein, Silverman), Columbia University Medical Center, and F.L. Lizzi Center for Biomedical Engineering (Silverman), Riverside Research, New York, New York, USA; London Vision Clinic (Reinstein), London, United Kingdom; Centre Hospitalier National d'Ophtalmologie (Reinstein), Paris, France.
J Cataract Refract Surg. 2016 Jan;42(1):95-101. doi: 10.1016/j.jcrs.2015.07.038.
To compare corneal thickness and epithelial thickness measurements in maps obtained using the RTVue spectral domain optical coherence tomography (SD-OCT) system and the Artemis 2 immersion arc-scanning very-high-frequency ultrasound (VHF-US) system.
Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA.
Comparative study.
Eyes of normal volunteers were scanned with the SD-OCT system followed by the VHF-US system and then again by the SD-OCT system. On each map, the minimum corneal thickness and mean values of corneal thickness and epithelial thickness in the 3.0 mm radius zone and in 0.5 mm wide concentric annuli of up to a 3.0 mm radius around the corneal vertex were determined.
Both eyes of 12 normal volunteers were scanned. The corneal thickness values from both devices were highly correlated (R > 0.96); in the 3.0 mm radius zone, they were not statistically significantly different. There was no statistically significant change in epithelial thickness or corneal thickness in SD-OCT measurements taken before versus after immersion US. Although highly correlated (R > 0.76), the SD-OCT epithelial thickness values were systematically thinner (1.7 ± 2.1 μm) than the VHF-US measurements in the 3.0 mm radius zone (P < .01).
The corneal thickness measurements in the 3.0 mm radius zone in normal eyes were equivalent between the 2 systems. Although correlated, the VHF-US epithelial thickness measurements were systemically thicker than the SD-OCT values.
Drs. Silverman and Reinstein have a commercial interest in Arcscan, Inc. Dr. Reinstein is a consultant to Carl Zeiss Meditec. None of the other authors has a financial or proprietary interest in any material or method presented.
比较使用RTVue光谱域光学相干断层扫描（SD-OCT）系统和Artemis 2浸入式弧扫描超高频超声（VHF-US）系统获得的地图中的角膜厚度和上皮厚度测量值。
美国纽约哥伦比亚大学医学中心眼科。
比较研究。
对正常志愿者的眼睛先用SD-OCT系统进行扫描，然后用VHF-US系统扫描，之后再用SD-OCT系统扫描。在每张地图上，确定角膜顶点周围半径3.0 mm区域以及半径达3.0 mm的0.5 mm宽同心环带中的最小角膜厚度、角膜厚度平均值和上皮厚度平均值。
对12名正常志愿者的双眼进行了扫描。两种设备测得的角膜厚度值高度相关（R>0.96）；在半径3.0 mm区域，两者无统计学显著差异。浸入式超声检查前后SD-OCT测量的上皮厚度或角膜厚度无统计学显著变化。尽管高度相关（R>0.76），但在半径3.0 mm区域，SD-OCT测量的上皮厚度值比VHF-US测量值系统性更薄（1.7±2.1μm）（P<0.01）。
两种系统测得的正常眼半径3.0 mm区域的角膜厚度相当。尽管相关，但VHF-US测量的上皮厚度系统性地比SD-OCT值更厚。
西尔弗曼博士和莱因斯坦博士在Arcscan公司拥有商业利益。莱因斯坦博士是卡尔蔡司医疗技术公司的顾问。其他作者均未对文中提及的任何材料或方法拥有财务或专利权益。
