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非甾体抗炎药在 LASIK 术后因创伤性瓣移位导致角膜上皮内植入中的应用:病例报告。

Use of nonsteroidal anti-inflammatory drugs in corneal epithelial ingrowth due to traumatic flap dislocation after LASIK: Case report.

机构信息

Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

出版信息

Medicine (Baltimore). 2024 Mar 1;103(9):e37333. doi: 10.1097/MD.0000000000037333.

DOI:10.1097/MD.0000000000037333
PMID:38428893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10906636/
Abstract

RATIONALE

Ophthalmologists mainly treat epithelial ingrowth by lifting the flap and scraping the ingrowth or using scraping combined with phototherapeutic keratectomy, mitomycin C, and so on. The potential usefulness of nonsteroidal anti-inflammatory drugs in such circumstances has not been reported before.

PATIENT CONCERNS

A 32-year-old man and a 25-year-old man underwent lifting and scraping of the flap and phototherapeutic keratectomy to remove the epithelial ingrowths. Unfortunately, the ingrowths recurred and continued to develop.

DIAGNOSIS

The patients were diagnosed with corneal epithelial ingrowth.

INTERVENTIONS

The administration of bromfenac sodium and fluorometholone eye drops.

OUTCOMES

Epithelial ingrowths in both patients disappeared after 6 and 1 month of treatment, respectively. There were no adverse reactions to the eye drops.

LESSONS

Nonsteroidal anti-inflammatory drugs may be broadly applied in the treatment of epithelial ingrowth after laser in situ keratomileusis.

摘要

背景

眼科医生主要通过掀起角膜瓣并刮除赘生物,或采用刮除联合光动力角膜切削术、丝裂霉素 C 等方法治疗角膜上皮内植入物。然而,此前尚未有研究报道非甾体类抗炎药在这种情况下的潜在用途。

患者关注

两名患者,分别为 32 岁男性和 25 岁男性,均接受了掀起角膜瓣和光动力角膜切削术以去除角膜上皮内植入物。遗憾的是,植入物复发并持续发展。

诊断

患者被诊断为角膜上皮内植入物。

干预措施

给予溴芬酸钠和氟米龙滴眼液滴眼。

结果

两名患者在接受治疗 6 个月和 1 个月后,角膜上皮内植入物均消失,且未见滴眼液相关不良反应。

结论

非甾体类抗炎药可能广泛应用于激光原位角膜磨镶术后角膜上皮内植入物的治疗。

相似文献

1
Use of nonsteroidal anti-inflammatory drugs in corneal epithelial ingrowth due to traumatic flap dislocation after LASIK: Case report.非甾体抗炎药在 LASIK 术后因创伤性瓣移位导致角膜上皮内植入中的应用:病例报告。
Medicine (Baltimore). 2024 Mar 1;103(9):e37333. doi: 10.1097/MD.0000000000037333.
2
Management of recalcitrant epithelial ingrowth after laser in situ keratomileusis: A case report.准分子原位角膜磨镶术后难治性上皮内生的处理:一例报告
Medicine (Baltimore). 2018 Oct;97(43):e13024. doi: 10.1097/MD.0000000000013024.
3
Flap amputation with phototherapeutic keratectomy (PTK) and adjuvant mitomycin C for severe post-LASIK epithelial ingrowth.采用光动力角膜切削术(PTK)联合辅助丝裂霉素C进行瓣切除术治疗严重的准分子激光原位角膜磨镶术(LASIK)后上皮内生。
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Epithelial ingrowth after LASIK treatment with scraping and phototherapeutic keratectomy.准分子激光原位角膜磨镶术联合刮除术及光治疗性角膜切削术后的上皮内生
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Int Ophthalmol. 2019 Jun;39(6):1397-1403. doi: 10.1007/s10792-018-0946-7. Epub 2018 May 12.

本文引用的文献

1
Epithelial ingrowth following laser in situ keratomileusis (LASIK): prevalence, risk factors, management and visual outcomes.准分子原位角膜磨镶术(LASIK)后上皮内生:发生率、危险因素、处理及视觉转归
BMJ Open Ophthalmol. 2018 Mar 29;3(1):e000133. doi: 10.1136/bmjophth-2017-000133. eCollection 2018.
2
Management of recurrent epithelial ingrowth following laser in situ keratomileusis with mechanical debridement, alcohol, mitomycin-C, and fibrin glue.采用机械清创、酒精、丝裂霉素 C 和纤维蛋白胶治疗激光原位角膜磨镶术后复发性上皮内植入的管理。
J Cataract Refract Surg. 2017 Jul;43(7):980-984. doi: 10.1016/j.jcrs.2017.07.001.
3
Traumatic corneal flap displacement after laser in situ keratomileusis (LASIK).
准分子原位角膜磨镶术(LASIK)后创伤性角膜瓣移位
Int Med Case Rep J. 2017 Apr 19;10:143-148. doi: 10.2147/IMCRJ.S128637. eCollection 2017.
4
Corneal Densitometry as a Tool to Measure Epithelial Ingrowth After Laser In Situ Keratomileusis.角膜密度测定法作为测量准分子原位角膜磨镶术后上皮内生的一种工具
Cornea. 2017 Apr;36(4):406-410. doi: 10.1097/ICO.0000000000001114.
5
Comparison of very-high-frequency ultrasound and spectral-domain optical coherence tomography corneal and epithelial thickness maps.超高频率超声与频域光学相干断层扫描角膜及上皮厚度图的比较。
J Cataract Refract Surg. 2016 Jan;42(1):95-101. doi: 10.1016/j.jcrs.2015.07.038.
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Localized flap melt after Nd-YAG laser treatment in recurrent post-LASIK epithelial ingrowth.
Arq Bras Oftalmol. 2015 Jul-Aug;78(4):250-1. doi: 10.5935/0004-2749.20150064.
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Pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs in retinochoroidal tissues in rabbits.局部应用非甾体抗炎药在兔视网膜脉络膜组织中的药代动力学及疗效
PLoS One. 2014 May 5;9(5):e96481. doi: 10.1371/journal.pone.0096481. eCollection 2014.
8
Bromfenac ophthalmic solution 0.07% dosed once daily for cataract surgery: results of 2 randomized controlled trials.溴芬酸钠滴眼液 0.07% 每日一次用于白内障手术:两项随机对照试验的结果。
Ophthalmology. 2014 Jan;121(1):25-33. doi: 10.1016/j.ophtha.2013.07.006. Epub 2013 Sep 8.
9
[Inhibitory effect of diclofenac sodium on the proliferation of rabbit corneal epithelial cells in vitro].
Yan Ke Xue Bao. 2010 Nov;25(2):107-10. doi: 10.3969/g.issn.1000-4432.2010.02.012.
10
Epithelial ingrowth after LASIK treatment with scraping and phototherapeutic keratectomy.准分子激光原位角膜磨镶术联合刮除术及光治疗性角膜切削术后的上皮内生
Acta Ophthalmol Scand. 2004 Dec;82(6):707-13. doi: 10.1111/j.1600-0420.2004.00375.x.