Vakilian Farveh, Attaran Davod, Shegofte Maysam, Lari Shahrzad, Ghare Sahar
Preventive Atherosclerotic Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Res Cardiovasc Med. 2016 Mar 5;5(2):e29361. doi: 10.5812/cardiovascmed.29361. eCollection 2016 May.
Idiopathic pulmonary hypertension (IPAH) is a rare, debilitating, and fatal disease. Late-onset treatment can lead to right heart failure, multiple organ damage, and death. Since the thyroid plays a major role in the metabolism and hemodynamics in humans, the screening of thyroid function is crucial. Thyroid dysfunction has been reported to cause pulmonary hypertension, but the thyroid is also involved in IPAH.
The aim of this study was to evaluate thyroid function in IPAH patients.
Fifty-three IPAH patients aged 16 - 75 years-old were enrolled in this cross sectional study, and their right ventricular functions, hemodynamics, and six minute walk tests (SMWTs) were evaluated. Thyroid function tests were conducted, and their associations with the patients' pulmonary arterial pressures (PAPs) and functional capacities were assessed. The data were analyzed using the SPSS 15 statistical software.
In this research, 84.8% of the participants were women. The mean PAP was 51.6 mmHg (31-87) and mean thyroid stimulating hormone (TSH) level was 4.2 mIU/ml (0.7 - 10). Subclinical hypothyroidism was detected in 26 patients (49.1%). There were significant correlations of the TSH level with the right ventricular (RV) end diastolic dimension (P value = 0.05) and triiodothyronine (T3) with the tricuspid annular plane systolic excursion (TAPSE) (P value = 0.04), an inverse relationship between the SMWT and the TSH level (P value = 0.004), but no significant relationship between these parameters and the thyroxine (T4) level.
IPAH is associated with subclinical hypothyroidism and low patient functional capacity, and is more common in RV failure.
特发性肺动脉高压（IPAH）是一种罕见、使人衰弱且致命的疾病。晚期治疗可导致右心衰竭、多器官损害及死亡。由于甲状腺在人体新陈代谢和血流动力学中起主要作用，因此甲状腺功能筛查至关重要。据报道，甲状腺功能障碍可导致肺动脉高压，但甲状腺也与IPAH有关。
本研究旨在评估IPAH患者的甲状腺功能。
本横断面研究纳入了53例年龄在16至75岁之间的IPAH患者，评估了他们的右心室功能、血流动力学及六分钟步行试验（SMWT）。进行了甲状腺功能测试，并评估了其与患者肺动脉压（PAP）及功能能力的相关性。使用SPSS 15统计软件对数据进行分析。
在本研究中，84.8%的参与者为女性。平均PAP为51.6 mmHg（31 - 87），平均促甲状腺激素（TSH）水平为4.2 mIU/ml（0.7 - 10）。26例患者（49.1%）检测出亚临床甲状腺功能减退。TSH水平与右心室（RV）舒张末期内径显著相关（P值 = 0.05），三碘甲状腺原氨酸（T3）与三尖瓣环平面收缩期位移（TAPSE）显著相关（P值 = 0.04），SMWT与TSH水平呈负相关（P值 = 0.004），但这些参数与甲状腺素（T4）水平之间无显著关系。
IPAH与亚临床甲状腺功能减退及患者低功能能力相关，且在右心衰竭中更为常见。
