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毒蛛毒素和哇巴因对粗制突触体组分中蛋白质磷酸化的影响。

Effect of tityustoxin and ouabain on protein phosphorylation in a crude synaptosome fraction.

作者信息

Ribeiro A M, Resende S R, Gomez M V

机构信息

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

出版信息

Braz J Med Biol Res. 1989;22(5):547-54.

PMID:2695192
Abstract
  1. The effect of tityustoxin (TsTX) and ouabain on the incorporation of 32P into a protein of the same apparent molecular weight as synapsin I is described. 2. Tityustoxin-stimulated protein phosphorylation in a crude synaptosome fraction increased up to a concentration of 3.0 microM at an incubation time of 15 s. 3. Trifluoperazine (100 microM) inhibited, while trifluoperazine sulphoxide (100 microM) did not alter the effect on the protein phosphorylation induced by tityustoxin. 4. Unlike tityustoxin, ouabain (100 microM) had no effect on protein phosphorylation even after incubation up to 20 min. 5. Ouabain at 10 microM, a concentration having no effect on rates of respiration and ATP hydrolysis in brain cortical slices, also had no effect on protein phosphorylation.
摘要
  1. 描述了毒蜘蛛毒素（TsTX）和哇巴因对32P掺入与突触结合蛋白I表观分子量相同的一种蛋白质的影响。2. 在粗制突触体组分中，毒蜘蛛毒素刺激的蛋白质磷酸化在15秒的孵育时间内，浓度高达3.0微摩尔时增加。3. 三氟拉嗪（100微摩尔）有抑制作用，而三氟拉嗪亚砜（100微摩尔）不改变毒蜘蛛毒素诱导的蛋白质磷酸化作用。4. 与毒蜘蛛毒素不同，即使孵育长达20分钟，哇巴因（100微摩尔）对蛋白质磷酸化也没有影响。5. 10微摩尔的哇巴因，该浓度对脑皮质切片的呼吸速率和ATP水解速率没有影响，对蛋白质磷酸化也没有影响。

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