Mehta Amar J, Zanobetti Antonella, Bind Marie-Abele C, Kloog Itai, Koutrakis Petros, Sparrow David, Vokonas Pantel S, Schwartz Joel D
Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Environ Health Perspect. 2016 Sep;124(9):1353-60. doi: 10.1289/ehp.1510269. Epub 2016 Mar 8.
It is unknown if ambient fine particulate matter (PM2.5) is associated with lower renal function, a cardiovascular risk factor.
We investigated whether long-term PM2.5 exposure was associated with estimated glomerular filtration rate (eGFR) in a cohort of older men living in the Boston Metropolitan area.
This longitudinal analysis included 669 participants from the Veterans Administration Normative Aging Study with up to four visits between 2000 and 2011 (n = 1,715 visits). Serum creatinine was measured at each visit, and eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration equation. One-year exposure to PM2.5 prior to each visit was assessed using a validated spatiotemporal model that utilized satellite remote-sensing aerosol optical depth data. eGFR was modeled in a time-varying linear mixed-effects regression model as a continuous function of 1-year PM2.5, adjusting for important covariates.
One-year PM2.5 exposure was associated with lower eGFRs; a 2.1-μg/m3 interquartile range higher 1-year PM2.5 was associated with a 1.87 mL/min/1.73 m2 lower eGFR [95% confidence interval (CI): -2.99, -0.76]. A 2.1 μg/m3-higher 1-year PM2.5 was also associated with an additional annual decrease in eGFR of 0.60 mL/min/1.73 m2 per year (95% CI: -0.79, -0.40).
In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline.
Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353-1360; http://dx.doi.org/10.1289/ehp.1510269.
环境细颗粒物（PM2.5）是否与作为心血管危险因素的肾功能降低相关尚不清楚。
我们调查了长期暴露于PM2.5是否与居住在波士顿都会区的老年男性队列中的估算肾小球滤过率（eGFR）相关。
这项纵向分析纳入了退伍军人管理局规范老化研究中的669名参与者，在2000年至2011年间进行了多达4次随访（n = 1715次随访）。每次随访时测量血清肌酐，并根据慢性肾脏病流行病学协作组方程计算eGFR。使用经过验证的时空模型评估每次随访前一年的PM2.5暴露情况，该模型利用卫星遥感气溶胶光学厚度数据。在时变线性混合效应回归模型中，将eGFR作为1年PM2.5的连续函数进行建模，并对重要协变量进行调整。
1年的PM2.5暴露与较低的eGFR相关；1年PM2.5的四分位间距每增加2.1μg/m3，eGFR就会降低1.87 mL/min/1.73 m2 [95%置信区间（CI）：-2.99，-0.76]。1年PM2.5每增加2.1μg/m3，还与eGFR每年额外降低0.60 mL/min/1.73 m2相关（95% CI：-0.79，-0.40）。
在这个老年男性纵向样本中，研究结果支持了长期暴露于PM2.5会对肾功能产生负面影响并加速肾功能下降这一假设。
Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353-1360; http://dx.doi.org/10.1289/ehp.1510269.
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