一个敏感话题：慢性偏头痛人群中皮肤异常性疼痛的评估
A touchy subject: an assessment of cutaneous allodynia in a chronic migraine population.
作者信息
Mathew Paul G, Cutrer Fred Michael, Garza Ivan
机构信息
Department of Neurology, John R Graham Headache Center, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
出版信息
J Pain Res. 2016 Feb 24;9:101-4. doi: 10.2147/JPR.S103238. eCollection 2016.
BACKGROUND
Cutaneous allodynia (CA) is a common feature of migraine, which has a complex underlying pathophysiology that is not well understood. In addition to pain, photophobia, phonophobia, osmophobia, nausea, and vomiting, CA can contribute to the overall disability caused by migraine. The presence of CA can be established via a validated questionnaire. Validated questionnaires and other tests are rarely performed in clinical practice. As such, current prevalence estimates for CA may be an underestimation.
METHODS
Utilizing a validated questionnaire, we assessed the presence of CA in consecutive patients (n=44) presenting with chronic migraine at a tertiary headache center.
RESULTS
CA appears to be quite prevalent, at ~90%, among female patients with chronic migraine.
CONCLUSION
CA prevalence in chronic migraine may be underestimated in the literature, and larger studies may better demonstrate a more accurate estimate of its prevalence.
背景
皮肤性疼痛过敏（CA）是偏头痛的常见特征，其潜在的病理生理学复杂，尚未完全明确。除疼痛外，畏光、畏声、畏嗅、恶心和呕吐，CA会导致偏头痛引起的整体功能障碍。CA的存在可通过经过验证的问卷来确定。在临床实践中，很少进行经过验证的问卷和其他测试。因此，目前对CA患病率的估计可能偏低。
方法
我们使用经过验证的问卷，对一家三级头痛中心连续就诊的慢性偏头痛患者（n = 44）进行了CA评估。
结果
在慢性偏头痛女性患者中，CA的患病率似乎相当高，约为90%。
结论
文献中可能低估了慢性偏头痛中CA的患病率，更大规模的研究可能会更好地更准确地估计其患病率。
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