用于内皮疾病的纳米药物。
Nanomedicines for Endothelial Disorders.
作者信息
Chung Bomy Lee, Toth Michael J, Kamaly Nazila, Sei Yoshitaka J, Becraft Jacob, Mulder Willem J M, Fayad Zahi A, Farokhzad Omid C, Kim YongTae, Langer Robert
机构信息
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Department of Chemical Engineering, Massachusetts Institute of Technology.
George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology (IEN), Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Georgia Institute of Technology.
出版信息
Nano Today. 2015 Dec 1;10(6):759-776. doi: 10.1016/j.nantod.2015.11.009.
The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications.
内皮细胞衬于血管和淋巴管的内表面，在维持体内平衡方面发挥着关键作用。内皮功能障碍涉及许多疾病和病症的病理过程，包括糖尿病、心血管疾病和癌症等病症。鉴于一系列疾病存在这种共同病因，针对受损内皮的药物可以增强治疗手段。纳米医学——将纳米技术应用于医疗保健——为治疗与内皮受损相关的疾病带来了新的机遇和潜力。本文综述讨论了目前可用于治疗这些病症的疗法，并着重介绍了纳米医学在治疗这些主要疾病并发症方面的应用。
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