用于功能失调性巨噬细胞相关疾病的纳米药物。
Nanomedicines for dysfunctional macrophage-associated diseases.
作者信息
He Hongliang, Ghosh Shobha, Yang Hu
机构信息
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States.
Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States.
出版信息
J Control Release. 2017 Feb 10;247:106-126. doi: 10.1016/j.jconrel.2016.12.032. Epub 2017 Jan 3.
Macrophages play vital functions in host inflammatory reaction, tissue repair, homeostasis and immunity. Dysfunctional macrophages have significant pathophysiological impacts on diseases such as cancer, inflammatory diseases (rheumatoid arthritis and inflammatory bowel disease), metabolic diseases (atherosclerosis, diabetes and obesity) and major infections like human immunodeficiency virus infection. In view of this common etiology in these diseases, targeting the recruitment, activation and regulation of dysfunctional macrophages represents a promising therapeutic strategy. With the advancement of nanotechnology, development of nanomedicines to efficiently target dysfunctional macrophages can strengthen the effectiveness of therapeutics and improve clinical outcomes. This review discusses the specific roles of dysfunctional macrophages in various diseases and summarizes the latest advances in nanomedicine-based therapeutics and theranostics for treating diseases associated with dysfunctional macrophages.
巨噬细胞在宿主炎症反应、组织修复、内环境稳态及免疫中发挥着至关重要的作用。功能失调的巨噬细胞对癌症、炎症性疾病（类风湿性关节炎和炎症性肠病）、代谢性疾病（动脉粥样硬化、糖尿病和肥胖症）以及人类免疫缺陷病毒感染等重大感染性疾病具有显著的病理生理影响。鉴于这些疾病存在共同的病因，针对功能失调巨噬细胞的募集、激活和调控是一种很有前景的治疗策略。随着纳米技术的进步，开发能够有效靶向功能失调巨噬细胞的纳米药物可以增强治疗效果并改善临床结局。本文综述了功能失调巨噬细胞在各种疾病中的具体作用，并总结了基于纳米医学的治疗方法和诊疗手段在治疗与功能失调巨噬细胞相关疾病方面的最新进展。
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