Rajakumar Kumaravel, Moore Charity G, Yabes Jonathan, Olabopo Flora, Haralam Mary Ann, Comer Diane, Holick Michael F, Greenspan Susan L
Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Dickson Advanced Analytics Group, Carolinas HealthCare System, Charlotte, North Carolina.
Pediatr Res. 2016 Jul;80(1):14-20. doi: 10.1038/pr.2016.46. Epub 2016 Mar 9.
The Institute of Medicine (IOM) dietary guidelines for vitamin D are based on limited pediatric data. Our objective was to estimate the dietary vitamin D requirements for maintaining serum 25-hydroxyvitamin D [25(OH)D] concentrations at the various IOM-considered thresholds of vitamin D status (12, 16, and 20 ng/ml) during fall and winter in children.
Ninety-six healthy 8- to 14-y-old Pittsburgh-area black and white children enrolled in a randomized, placebo-controlled trial of vitamin D3 1,000 IU daily for 6 mo with baseline and 2-mo follow-up assessments completed during October through April were studied. Vitamin D intake from diet and study supplement adjusted for adherence and serum 25(OH)D were measured.
The vitamin D intakes needed to maintain serum 25(OH)D concentrations at 12, 16, and 20 ng/ml in 90% of the children were 581, 1,062, and 1543 IU/day, respectively. The estimated vitamin D intakes needed to maintain serum 25(OH)D concentrations at 20 ng/ml in 97.5% of the children was 2,098 IU/day.
Our data suggest that the current vitamin D recommended dietary allowance (RDA) (600 IU/day) is insufficient to cover the skeletal health needs of at least 50% of black and white children.
美国医学研究所(IOM)的维生素D膳食指南所依据的儿科数据有限。我们的目标是估计在秋冬季节维持儿童血清25-羟基维生素D [25(OH)D] 浓度处于IOM所考虑的不同维生素D状态阈值(12、16和20 ng/ml)时的膳食维生素D需求量。
对96名年龄在8至14岁、来自匹兹堡地区的健康黑人和白人儿童进行了研究,这些儿童参与了一项随机、安慰剂对照试验,每天服用1000 IU维生素D3,为期6个月,并在10月至4月期间完成了基线和2个月的随访评估。测量了饮食和研究补充剂中的维生素D摄入量,并根据依从性和血清25(OH)D进行了调整。
90%的儿童将血清25(OH)D浓度维持在12、16和20 ng/ml时所需的维生素D摄入量分别为581、1062和1543 IU/天。97.5%的儿童将血清25(OH)D浓度维持在20 ng/ml时所需的估计维生素D摄入量为2098 IU/天。
我们的数据表明,目前的维生素D膳食推荐摄入量(RDA)(600 IU/天)不足以满足至少50%的黑人和白人儿童骨骼健康的需求。