Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Clin Immunol. 2016 Apr;165:29-34. doi: 10.1016/j.clim.2016.03.001. Epub 2016 Mar 4.
A reduced level of the single-pass transmembrane protein α-Klotho is known to be associated with neuronal damage. We investigated whether α-Klotho in cerebrospinal fluid (CSF) could be a candidate marker for the diagnosis of neuropsychiatric systemic lupus erythematosus (NPSLE). We analyzed the laboratory data, symptoms and radiological image findings of 34 NPSLE patients. Patients with SLE without neuropsychiatric manifestations (SLE) (n=25), and patients with viral meningitis (VM) (n=19), multiple sclerosis (MS) (n=20) or neuromyelitis optica (NMO) (n=20) were included as controls. The multivariable analyses revealed that lower CSF α-Klotho level, lower serum anti-Smith antibodies (U/mL) and higher serum C3 (mg/dL) were significant factors for predicting NPSLE. The CSF α-Klotho levels of the NPSLE patients were inversely correlated with the level of granulocyte/macrophage-colony stimulating factor. Our data suggested that the determination of CSF α-Klotho levels will contribute to the diagnosis of NPSLE and help elucidate the mechanisms underlying this disease.
已知单通道跨膜蛋白α-Klotho 的水平降低与神经元损伤有关。我们研究了脑脊液（CSF）中的α-Klotho 是否可以作为神经精神性系统性红斑狼疮（NPSLE）诊断的候选标志物。我们分析了 34 名 NPSLE 患者的实验室数据、症状和影像学图像发现。将 SLE 无神经精神表现的患者（SLE）（n=25）、病毒性脑膜炎（VM）（n=19）、多发性硬化症（MS）（n=20）或视神经脊髓炎（NMO）（n=20）患者作为对照。多变量分析显示，较低的 CSF α-Klotho 水平、较低的血清抗-Smith 抗体（U/mL）和较高的血清 C3（mg/dL）是预测 NPSLE 的重要因素。NPSLE 患者的 CSF α-Klotho 水平与粒细胞/巨噬细胞集落刺激因子的水平呈负相关。我们的数据表明，CSF α-Klotho 水平的测定将有助于 NPSLE 的诊断，并有助于阐明该疾病的发病机制。
