细菌中的胆固醇脂质和含胆固醇的脂筏。
Cholesterol lipids and cholesterol-containing lipid rafts in bacteria.
作者信息
Huang Zhen, London Erwin
机构信息
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794-5215 USA.
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 11794-5215 USA.
出版信息
Chem Phys Lipids. 2016 Sep;199:11-16. doi: 10.1016/j.chemphyslip.2016.03.002. Epub 2016 Mar 7.
Abstract
Sterols are important components of eukaryotic membranes, but rare in bacteria. Some bacteria obtain sterols from their host or environment. In some cases, these sterols form membrane domains analogous the lipid rafts proposed to exist in eukaryotic membranes. This review describes the properties and roles of sterols in Borrelia and Helicobacter.
摘要
甾醇是真核细胞膜的重要组成部分，但在细菌中却很罕见。一些细菌从宿主或环境中获取甾醇。在某些情况下，这些甾醇会形成类似于真核细胞膜中存在的脂筏的膜结构域。这篇综述描述了甾醇在疏螺旋体属和幽门螺杆菌中的特性和作用。
相似文献
1
Cholesterol lipids and cholesterol-containing lipid rafts in bacteria.细菌中的胆固醇脂质和含胆固醇的脂筏。
Chem Phys Lipids. 2016 Sep;199:11-16. doi: 10.1016/j.chemphyslip.2016.03.002. Epub 2016 Mar 7.
2
Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function.神经酰胺可选择性地将胆固醇从有序脂质结构域（脂筏）中置换出来：对脂筏结构与功能的影响。
J Biol Chem. 2004 Mar 12;279(11):9997-10004. doi: 10.1074/jbc.M309992200. Epub 2003 Dec 29.
3
Proving lipid rafts exist: membrane domains in the prokaryote Borrelia burgdorferi have the same properties as eukaryotic lipid rafts.证明脂筏的存在：原核生物伯氏疏螺旋体中的膜域具有与真核脂筏相同的性质。
PLoS Pathog. 2013;9(5):e1003353. doi: 10.1371/journal.ppat.1003353. Epub 2013 May 16.
4
Sterol carrier protein-2 selectively alters lipid composition and cholesterol dynamics of caveolae/lipid raft vs nonraft domains in L-cell fibroblast plasma membranes.固醇载体蛋白-2选择性地改变L细胞成纤维细胞质膜中小窝/脂筏与非脂筏结构域的脂质组成和胆固醇动力学。
Biochemistry. 2003 Dec 16;42(49):14583-98. doi: 10.1021/bi034966+.
5
Using Sterol Substitution to Probe the Role of Membrane Domains in Membrane Functions.利用甾醇替代法探究膜结构域在膜功能中的作用。
Lipids. 2015 Aug;50(8):721-34. doi: 10.1007/s11745-015-4007-y. Epub 2015 Mar 25.
6
Lipids and lipid domains of the yeast vacuole.酵母液泡的脂质和脂质域。
Biochem Soc Trans. 2018 Oct 19;46(5):1047-1054. doi: 10.1042/BST20180120. Epub 2018 Sep 20.
7
Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders.胆固醇前体对普通的富含神经酰胺的有序脂质结构域（脂筏）有不同程度的稳定作用。对布洛赫假说和固醇生物合成紊乱的影响。
J Biol Chem. 2006 Aug 4;281(31):21903-21913. doi: 10.1074/jbc.M600395200. Epub 2006 May 30.
8
Helicobacter pylori lipids can form ordered membrane domains (rafts).幽门螺杆菌脂质可以形成有序的膜域（筏）。
Biochim Biophys Acta Biomembr. 2019 Nov 1;1861(11):183050. doi: 10.1016/j.bbamem.2019.183050. Epub 2019 Aug 23.
9
10
Exposure of phosphatidylinositol transfer proteins to sphingomyelin-cholesterol membranes suggests transient but productive interactions with raft-like, liquid-ordered domains.磷脂酰肌醇转移蛋白与鞘磷脂 - 胆固醇膜的接触表明其与筏样、液晶有序结构域存在短暂但有效的相互作用。
Biochemistry. 2003 Nov 18;42(45):13250-9. doi: 10.1021/bi034616n.
引用本文的文献
1
Selectivity of membrane-active peptides: the role of electrostatics and other membrane biophysical properties.膜活性肽的选择性：静电作用及其他膜生物物理性质的作用
Biophys Rev. 2025 Apr 10;17(2):591-604. doi: 10.1007/s12551-025-01309-7. eCollection 2025 Apr.
2
Lipid Trafficking in Diverse Bacteria.不同细菌中的脂质转运
Acc Chem Res. 2025 Jan 7;58(1):36-46. doi: 10.1021/acs.accounts.4c00540. Epub 2024 Dec 16.
3
Natural Products Biosynthesis by IMV Ac-5025 under Exogenous Sterol Action.IMV Ac-5025在外源甾醇作用下的天然产物生物合成
Antibiotics (Basel). 2024 Feb 1;13(2):146. doi: 10.3390/antibiotics13020146.
4
The antimicrobial peptide Polybia-MP1 differentiates membranes with the hopanoid, diplopterol from those with cholesterol.抗菌肽Polybia-MP1能区分含有藿烷类化合物双萜醇的膜和含有胆固醇的膜。
BBA Adv. 2021 Jan 30;1:100002. doi: 10.1016/j.bbadva.2021.100002. eCollection 2021.
5
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas.必需蛋白 P116 为支原体提取胆固醇和其他必需脂质。
Nat Struct Mol Biol. 2023 Mar;30(3):321-329. doi: 10.1038/s41594-023-00922-y. Epub 2023 Feb 13.
6
New Antimicrobial Peptide with Two CRAC Motifs: Activity against and .具有两个CRAC基序的新型抗菌肽：对……和……的活性
Microorganisms. 2022 Jul 29;10(8):1538. doi: 10.3390/microorganisms10081538.
7
Use of host lipids by the Lyme disease spirochete may lead to biomarkers.莱姆病螺旋体利用宿主脂质可能导致生物标志物。
J Clin Invest. 2022 Mar 15;132(6). doi: 10.1172/JCI158254.
8
Enhanced enzymatic production of cholesteryl 6'-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori.增强型胆甾醇 6'-酰基葡萄糖苷酶的产生会损害溶酶体降解，从而促进幽门螺杆菌的细胞内生存。
J Biomed Sci. 2021 Oct 27;28(1):72. doi: 10.1186/s12929-021-00768-w.
9
Diet-Microbiota Interactions Alter Mosquito Development.饮食与微生物群的相互作用改变蚊子的发育。
Front Microbiol. 2021 Jun 8;12:650743. doi: 10.3389/fmicb.2021.650743. eCollection 2021.
10
Identification and functional analysis of a galactosyltransferase capable of cholesterol glycolipid formation in the Lyme disease spirochete Borrelia burgdorferi.鉴定和功能分析可在莱姆病螺旋体伯氏疏螺旋体中形成胆固醇糖脂的半乳糖基转移酶。
PLoS One. 2021 Jun 1;16(6):e0252214. doi: 10.1371/journal.pone.0252214. eCollection 2021.
本文引用的文献
1
The lipid raft proteome of Borrelia burgdorferi.伯氏疏螺旋体的脂筏蛋白质组
Proteomics. 2015 Nov;15(21):3662-75. doi: 10.1002/pmic.201500093. Epub 2015 Sep 28.
2
Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols.植物脂质对膜组织的差异作用：植物鞘脂和植物甾醇的特异性
J Biol Chem. 2015 Feb 27;290(9):5810-25. doi: 10.1074/jbc.M114.598805. Epub 2015 Jan 9.
3
Synthesis and structural characterization of three unique Helicobacter pylori α-cholesteryl phosphatidyl glucosides.三种独特的幽门螺杆菌α-胆固醇基磷脂酰葡萄糖苷的合成与结构表征
Angew Chem Int Ed Engl. 2014 Dec 1;53(49):13400-3. doi: 10.1002/anie.201406529. Epub 2014 Sep 4.
4
Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages.幽门螺杆菌引起的胆固醇糖苷化作用可延缓巨噬细胞内吞作用，并阻止吞噬体成熟。
J Microbiol Immunol Infect. 2016 Oct;49(5):636-645. doi: 10.1016/j.jmii.2014.05.011. Epub 2014 Jul 26.
5
Selective association of outer surface lipoproteins with the lipid rafts of Borrelia burgdorferi.外表面脂蛋白与伯氏疏螺旋体脂筏的选择性关联。
mBio. 2014 Mar 11;5(2):e00899-14. doi: 10.1128/mBio.00899-14.
6
Helicobacter pylori's cholesterol uptake impacts resistance to docosahexaenoic acid.幽门螺杆菌的胆固醇摄取影响对二十二碳六烯酸的抗性。
Int J Med Microbiol. 2014 May;304(3-4):314-20. doi: 10.1016/j.ijmm.2013.11.018. Epub 2013 Dec 1.
7
Proving lipid rafts exist: membrane domains in the prokaryote Borrelia burgdorferi have the same properties as eukaryotic lipid rafts.证明脂筏的存在：原核生物伯氏疏螺旋体中的膜域具有与真核脂筏相同的性质。
PLoS Pathog. 2013;9(5):e1003353. doi: 10.1371/journal.ppat.1003353. Epub 2013 May 16.
8
Lipid exchange between Borrelia burgdorferi and host cells.伯氏疏螺旋体与宿主细胞间的脂质交换。
PLoS Pathog. 2013 Jan;9(1):e1003109. doi: 10.1371/journal.ppat.1003109. Epub 2013 Jan 10.
9
Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation.胆固醇葡糖苷化使 7-脱氢胆固醇对幽门螺杆菌致命，这是其解毒作用的一个新角色。
J Bacteriol. 2013 Jan;195(2):359-67. doi: 10.1128/JB.01495-12. Epub 2012 Nov 9.
10
Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization.二十二碳六烯酸在体外抑制幽门螺杆菌生长和小鼠胃黏膜定植。
PLoS One. 2012;7(4):e35072. doi: 10.1371/journal.pone.0035072. Epub 2012 Apr 17.
Zotero 插件