Koonin Eugene V, Starokadomskyy Petro
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75235, USA.
Stud Hist Philos Biol Biomed Sci. 2016 Oct;59:125-34. doi: 10.1016/j.shpsc.2016.02.016. Epub 2016 Mar 7.
The question whether or not "viruses are alive" has caused considerable debate over many years. Yet, the question is effectively without substance because the answer depends entirely on the definition of life or the state of "being alive" that is bound to be arbitrary. In contrast, the status of viruses among biological entities is readily defined within the replicator paradigm. All biological replicators form a continuum along the selfishness-cooperativity axis, from the completely selfish to fully cooperative forms. Within this range, typical, lytic viruses represent the selfish extreme whereas temperate viruses and various mobile elements occupy positions closer to the middle of the range. Selfish replicators not only belong to the biological realm but are intrinsic to any evolving system of replicators. No such system can evolve without the emergence of parasites, and moreover, parasites drive the evolution of biological complexity at multiple levels. The history of life is a story of parasite-host coevolution that includes both the incessant arms race and various forms of cooperation. All organisms are communities of interacting, coevolving replicators of different classes. A complete theory of replicator coevolution remains to be developed, but it appears likely that not only the differentiation between selfish and cooperative replicators but the emergence of the entire range of replication strategies, from selfish to cooperative, is intrinsic to biological evolution.
“病毒是否有生命”这一问题多年来引发了诸多争论。然而,这个问题实际上并无实质意义,因为答案完全取决于生命的定义,或者说“有生命”的状态,而这必然是主观随意的。相比之下,在复制子范式中,病毒在生物实体中的地位很容易界定。所有生物复制子沿着自私 - 合作轴形成一个连续统,从完全自私到完全合作的形式。在这个范围内,典型的裂解性病毒代表着自私的极端,而温和病毒和各种移动元件则占据着更靠近范围中间的位置。自私的复制子不仅属于生物领域,而且是任何进化的复制子系统所固有的。没有寄生虫的出现,这样的系统就无法进化,此外,寄生虫在多个层面推动着生物复杂性的进化。生命的历史是一部寄生虫 - 宿主共同进化的故事,其中包括持续不断的军备竞赛和各种形式的合作。所有生物都是不同类别的相互作用、共同进化的复制子的群落。完整的复制子共同进化理论仍有待发展,但似乎不仅自私与合作复制子之间的分化,而且从自私到合作的整个复制策略范围的出现,都是生物进化所固有的。