Suppr超能文献

病毒是有生命的吗?复制子范式为一个古老但被误导的问题提供了决定性的线索。

Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question.

作者信息

Koonin Eugene V, Starokadomskyy Petro

机构信息

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, 75235, USA.

出版信息

Stud Hist Philos Biol Biomed Sci. 2016 Oct;59:125-34. doi: 10.1016/j.shpsc.2016.02.016. Epub 2016 Mar 7.

Abstract

The question whether or not "viruses are alive" has caused considerable debate over many years. Yet, the question is effectively without substance because the answer depends entirely on the definition of life or the state of "being alive" that is bound to be arbitrary. In contrast, the status of viruses among biological entities is readily defined within the replicator paradigm. All biological replicators form a continuum along the selfishness-cooperativity axis, from the completely selfish to fully cooperative forms. Within this range, typical, lytic viruses represent the selfish extreme whereas temperate viruses and various mobile elements occupy positions closer to the middle of the range. Selfish replicators not only belong to the biological realm but are intrinsic to any evolving system of replicators. No such system can evolve without the emergence of parasites, and moreover, parasites drive the evolution of biological complexity at multiple levels. The history of life is a story of parasite-host coevolution that includes both the incessant arms race and various forms of cooperation. All organisms are communities of interacting, coevolving replicators of different classes. A complete theory of replicator coevolution remains to be developed, but it appears likely that not only the differentiation between selfish and cooperative replicators but the emergence of the entire range of replication strategies, from selfish to cooperative, is intrinsic to biological evolution.

摘要

“病毒是否有生命”这一问题多年来引发了诸多争论。然而,这个问题实际上并无实质意义,因为答案完全取决于生命的定义,或者说“有生命”的状态,而这必然是主观随意的。相比之下,在复制子范式中,病毒在生物实体中的地位很容易界定。所有生物复制子沿着自私 - 合作轴形成一个连续统,从完全自私到完全合作的形式。在这个范围内,典型的裂解性病毒代表着自私的极端,而温和病毒和各种移动元件则占据着更靠近范围中间的位置。自私的复制子不仅属于生物领域,而且是任何进化的复制子系统所固有的。没有寄生虫的出现,这样的系统就无法进化,此外,寄生虫在多个层面推动着生物复杂性的进化。生命的历史是一部寄生虫 - 宿主共同进化的故事,其中包括持续不断的军备竞赛和各种形式的合作。所有生物都是不同类别的相互作用、共同进化的复制子的群落。完整的复制子共同进化理论仍有待发展,但似乎不仅自私与合作复制子之间的分化,而且从自私到合作的整个复制策略范围的出现,都是生物进化所固有的。

相似文献

1
Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question.
Stud Hist Philos Biol Biomed Sci. 2016 Oct;59:125-34. doi: 10.1016/j.shpsc.2016.02.016. Epub 2016 Mar 7.
2
A virocentric perspective on the evolution of life.
Curr Opin Virol. 2013 Oct;3(5):546-57. doi: 10.1016/j.coviro.2013.06.008. Epub 2013 Jul 12.
3
Virus world as an evolutionary network of viruses and capsidless selfish elements.
Microbiol Mol Biol Rev. 2014 Jun;78(2):278-303. doi: 10.1128/MMBR.00049-13.
4
Viruses Defined by the Position of the Virosphere within the Replicator Space.
Microbiol Mol Biol Rev. 2021 Dec 15;85(4):e0019320. doi: 10.1128/MMBR.00193-20. Epub 2021 Sep 1.
5
Viruses and mobile elements as drivers of evolutionary transitions.
Philos Trans R Soc Lond B Biol Sci. 2016 Aug 19;371(1701). doi: 10.1098/rstb.2015.0442.
7
Classification of prokaryotic genetic replicators: between selfishness and altruism.
Ann N Y Acad Sci. 2015 Apr;1341:96-105. doi: 10.1111/nyas.12696. Epub 2015 Feb 19.
8
Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution.
PLoS Comput Biol. 2022 Dec 1;18(12):e1010709. doi: 10.1371/journal.pcbi.1010709. eCollection 2022 Dec.
10
The origins of cellular life.
Antonie Van Leeuwenhoek. 2014 Jul;106(1):27-41. doi: 10.1007/s10482-014-0169-5. Epub 2014 Apr 23.

引用本文的文献

1
Nanoparticles: a promising tool against environmental stress in plants.
Front Plant Sci. 2025 Jan 27;15:1509047. doi: 10.3389/fpls.2024.1509047. eCollection 2024.
2
Virucidal Coatings Active Against SARS-CoV-2.
Molecules. 2024 Oct 20;29(20):4961. doi: 10.3390/molecules29204961.
3
Modern microbiology: Embracing complexity through integration across scales.
Cell. 2024 Sep 19;187(19):5151-5170. doi: 10.1016/j.cell.2024.08.028.
5
Systematic Review on Major Antiviral Phytocompounds from Common Medicinal Plants against SARS-CoV-2.
Med Chem. 2024;20(6):613-629. doi: 10.2174/0115734064262843231120051452.
6
An economon model of drug addiction.
Psychopharmacology (Berl). 2024 Mar;241(3):417-425. doi: 10.1007/s00213-024-06535-7. Epub 2024 Jan 26.
7
Coordinating virus research: The Virus Infectious Disease Ontology.
PLoS One. 2024 Jan 18;19(1):e0285093. doi: 10.1371/journal.pone.0285093. eCollection 2024.
8
Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes.
Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2301522120. doi: 10.1073/pnas.2301522120. Epub 2023 Mar 30.
9
Revealing In Silico that Bacteria's Outer Membrane Proteins may Help our Bodies Replicate and Carry Severe Acute Respiratory Syndrome Coronavirus 2.
Bioinform Biol Insights. 2022 Aug 8;16:11779322221116320. doi: 10.1177/11779322221116320. eCollection 2022.
10
How many ways can you die? Multiple biological deaths as a consequence of the multiple concepts of an organism.
Theor Med Bioeth. 2022 Jun;43(2-3):127-154. doi: 10.1007/s11017-022-09583-2. Epub 2022 Jul 20.

本文引用的文献

2
Origins and evolution of viruses of eukaryotes: The ultimate modularity.
Virology. 2015 May;479-480:2-25. doi: 10.1016/j.virol.2015.02.039. Epub 2015 Mar 12.
3
Ultrastructure of the replication sites of positive-strand RNA viruses.
Virology. 2015 May;479-480:418-33. doi: 10.1016/j.virol.2015.02.029. Epub 2015 Mar 6.
5
Classification of prokaryotic genetic replicators: between selfishness and altruism.
Ann N Y Acad Sci. 2015 Apr;1341:96-105. doi: 10.1111/nyas.12696. Epub 2015 Feb 19.
6
The eukaryotic way to defend and edit genomes by sRNA-targeted DNA deletion.
Ann N Y Acad Sci. 2015 Apr;1341:106-14. doi: 10.1111/nyas.12636. Epub 2015 Jan 7.
7
Evolution of adaptive immunity from transposable elements combined with innate immune systems.
Nat Rev Genet. 2015 Mar;16(3):184-92. doi: 10.1038/nrg3859. Epub 2014 Dec 9.
8
Virus-host arms race at the joint origin of multicellularity and programmed cell death.
Cell Cycle. 2014;13(19):3083-8. doi: 10.4161/15384101.2014.949496.
10
Cellular domains and viral lineages.
Trends Microbiol. 2014 Oct;22(10):554-8. doi: 10.1016/j.tim.2014.07.004. Epub 2014 Aug 13.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验