Genon Sarah, Li Hai, Fan Lingzhong, Müller Veronika I, Cieslik Edna C, Hoffstaedter Felix, Reid Andrew T, Langner Robert, Grefkes Christian, Fox Peter T, Moebus Susanne, Caspers Svenja, Amunts Katrin, Jiang Tianzi, Eickhoff Simon B
Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Cereb Cortex. 2017 Mar 1;27(3):2095-2110. doi: 10.1093/cercor/bhw065.
The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.
据报道，人类右侧背侧运动前区皮质（PMd）参与广泛的运动和认知功能。我们通过使用基于元分析方法的基于连接性的脑区划分来探索这种行为异质性的基础，该方法应用于PMd的共激活。我们将基于连接性的脑区划分结果与通过静息态功能连接和概率性扩散张量成像获得的脑区划分结果进行了比较。对所得PMd子区域的功能连接谱和行为解码能够表征它们各自的行为特征。这些程序将右侧PMd划分为5个不同的子区域，这些子区域沿着前后轴形成了一个认知-运动梯度。具体而言，我们发现：1）一个与前额叶皮质功能相连的 Rostral 子区域，可能支持高级认知过程，如工作记忆；2）一个中央子区域，表现出混合的行为特征，并与背侧注意网络的顶叶区域有功能连接；3）一个与运动系统紧密整合的尾侧子区域。此外，我们还发现：4）一个背侧子区域，优先与手部运动相关，并与认知和运动区域相连；5）一个腹侧子区域，其功能特征符合眼动相关区域的概念。总之，右侧PMd可被视为由5个子区域组成的功能镶嵌体。
