Knockenhauer Kevin E, Schwartz Thomas U
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell. 2016 Mar 10;164(6):1162-1171. doi: 10.1016/j.cell.2016.01.034.
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary transport gates for molecular exchange between nucleus and cytoplasm. Stripping the megadalton complex down to its most essential organizational elements, one can divide the NPC into scaffold components and the disordered elements attached to them that generate a selective barrier between compartments. These structural elements exhibit flexibility, which may hold a clue in understanding NPC assembly and function. Here we review the current status of NPC research with a focus on the functional implications of its structural and compositional heterogeneity.
核孔复合体（NPCs）贯穿核膜，是细胞核与细胞质之间分子交换的主要运输通道。将这个兆道尔顿级别的复合体分解为其最基本的组织元素，可以将NPC分为支架成分以及附着于其上的无序元素，这些无序元素在不同区室之间形成了一个选择性屏障。这些结构元素具有灵活性，这可能为理解NPC的组装和功能提供线索。在这里，我们综述了NPC研究的现状，重点关注其结构和组成异质性的功能意义。
